Gene

zap70

ID
ZDB-GENE-050522-257
Name
zeta chain of T cell receptor associated protein kinase 70
Symbol
zap70 Nomenclature History
Previous Names
  • zgc:110383
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Acts upstream of or within lymphangiogenesis and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in gut. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zap70 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 48 Alliance Immunodeficiency 48 269840
Autoimmune disease, multisystem, infantile-onset, 2 617006
Associated With zap70 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR035838 SYK/ZAP-70, N-terminal SH2 domain
Family IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR023420 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily SYK/ZAP-70, N-terminal SH2 domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, non-receptor SYK/ZAP-70 Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
UniProtKB:M9MM92 604
UniProtKB:Q503P3 604
UniProtKB:M9MMB1 218
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-zap70 monoclonal IgG Rabbit
  • IHC
Cell Signaling Technology, Inc.
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations