Gene
ttc39c
- ID
- ZDB-GENE-050522-194
- Name
- tetratricopeptide repeat domain 39C
- Symbol
- ttc39c Nomenclature History
- Previous Names
-
- si:ch73-264b7.2
- si:dkey-121a11.7
- zgc:110162
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Acts upstream of or within cilium assembly; determination of heart left/right asymmetry; and otolith morphogenesis. Is expressed in nervous system and trigeminal placode. Orthologous to human TTC39C (tetratricopeptide repeat domain 39C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110162 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Xu et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9410 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa12531 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16055 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19285 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24127 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa24128 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32395 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32396 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Inclusion body clearance protein Iml2/Tetratricopeptide repeat protein 39 | Tetratricopeptide-like helical domain superfamily |
|---|---|---|---|---|
| UniProtKB:Q1LXE6 | InterPro | 579 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ttc39c-201
(1)
|
Ensembl | 1,006 nt | ||
| mRNA |
ttc39c-202
(1)
|
Ensembl | 4,309 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-121A11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110162 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020568 (1) | 2998 nt | ||
| Genomic | GenBank:BX465190 (1) | 183103 nt | ||
| Polypeptide | UniProtKB:Q1LXE6 (1) | 579 aa |
- Xu, Y., Cao, J., Huang, S., Feng, D., Zhang, W., Zhu, X., Yan, X. (2015) Characterization of Tetratricopeptide Repeat-Containing Proteins Critical for Cilia Formation and Function. PLoS One. 10:e0124378
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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