Gene
cox5aa
- ID
- ZDB-GENE-050522-133
- Name
- cytochrome c oxidase subunit 5Aa
- Symbol
- cox5aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables cytochrome-c oxidase activity. Acts upstream of or within embryonic organ development and spinal cord motor neuron differentiation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; musculature system; and nervous system. Used to study ciliopathy and visceral heterotaxy. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 20. Orthologous to human COX5A (cytochrome c oxidase subunit 5A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb739 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
mitochondrial complex IV deficiency nuclear type 20 | Alliance | Mitochondrial complex IV deficiency, nuclear type 20 | 619064 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
visceral heterotaxy | WT + MO1-cox5aa | standard conditions | Burkhalter et al., 2019 |
ciliopathy | WT + MO1-cox5aa | standard conditions | Burkhalter et al., 2019 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cytochrome c oxidase, subunit Va/VI | Cytochrome c oxidase, subunit Va/VI superfamily |
---|---|---|---|---|
UniProtKB:Q4VBU7 | InterPro | 141 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
cox5aa-201
(1)
|
Ensembl | 690 nt | ||
mRNA |
cox5aa-202
(1)
|
Ensembl | 457 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-67P11 | ZFIN Curated Data | |
Contains | STS | chunp30169 | ||
Encodes | EST | cb739 | Thisse et al., 2001 | |
Encodes | EST | fj32b09 | ||
Encodes | cDNA | MGC:109989 | ZFIN Curated Data | |
Encodes | cDNA | MGC:114165 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191452 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001024403 (1) | 710 nt | ||
Genomic | GenBank:CR376821 (1) | 164689 nt | ||
Polypeptide | UniProtKB:Q4VBU7 (1) | 141 aa |
- Ruparelia, A.A., Montandon, M., Merriner, J., Huang, C., Wong, S.F.L., Sonntag, C., Hardee, J.P., Lynch, G.S., Miles, L.B., Siegel, A., Hall, T.E., Schittenhelm, R.B., Currie, P.D. (2024) Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP. JCI insight. 9(8):
- Wen, W., Guo, C., Chen, Z., Yang, D., Zhu, D., Jing, Q., Zheng, L., Sun, C., Tang, C. (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. PLoS One. 18:e0294700e0294700
- Ivantsova, E., Wengrovitz, A.S., Souders, C.L., Martyniuk, C.J. (2022) Developmental and behavioral toxicity assessment of glyphosate and its main metabolite aminomethylphosphonic acid (AMPA) in zebrafish embryos/larvae. Environmental Toxicology and Pharmacology. 93:103873
- Zhang, X., Ivantsova, E., Perez-Rodriguez, V., Cao, F., Souders, C.L., Martyniuk, C.J. (2022) Investigating mitochondria-immune responses in zebrafish, Danio rerio (Hamilton, 1822): A case study with the herbicide dinoseb. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 257:109357
- Maharaj, S., El Ahmadie, N., Rheingold, S., El-Chehouri, J., Yang, L., Souders, C.L., Martyniuk, C.J. (2020) Sub-lethal toxicity assessment of the phenylurea herbicide linuron in developing zebrafish (Danio rerio) embryo/larvae. Neurotoxicology and teratology. 81:106917
- Burkhalter, M.D., Sridhar, A., Sampaio, P., Jacinto, R., Burczyk, M.S., Donow, C., Angenendt, M., Investigators, C.N.F.C.H.D., Hempel, M., Walther, P., Pennekamp, P., Omran, H., Lopes, S.S., Ware, S.M., Philipp, M. (2019) Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. The Journal of Clinical Investigation. 130:2841-2855
- Teixeira, C.M.M., Correa, C.N., Iwai, L.K., Ferro, E.S., Castro, L.M. (2019) Characterization of Intracellular Peptides from Zebrafish (Danio rerio) Brain. Zebrafish. 16(3):240-251
- Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R.I., Lefkopoulos, S., Yin, N., Cauchy, P., Curtis, J.D., Klaeylé, L., Langa, X., Beckmann, C.C.A., Wlodarski, M.W., Müller, P., Van Essen, D., Rambold, A., Kapp, F.G., Mione, M., Buescher, J.M., Pearce, E.L., Polyzos, A., Trompouki, E. (2018) A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature communications. 9:3090
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Chen, W.C., Wang, Z., Missinato, M.A., Park, D.W., Long, D.W., Liu, H.J., Zeng, X., Yates, N.A., Kim, K., Wang, Y. (2016) Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Science advances. 2:e1600844
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