Gene

orai1b

ID
ZDB-GENE-050522-100
Name
ORAI calcium release-activated calcium modulator 1b
Symbol
orai1b Nomenclature History
Previous Names
  • orai1
  • im:7146264
  • zgc:109721
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have store-operated calcium channel activity. Involved in sarcomere organization. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including head; heart; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Völkers et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With orai1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 9 Alliance Immunodeficiency 9 612782
tubular aggregate myopathy 2 Alliance Myopathy, tubular aggregate, 2 615883
Associated With orai1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR012446 Calcium release-activated calcium channel protein
Homologous_superfamily IPR038350 Orai superfamily
Domain Details Per Protein
Protein Length Calcium release-activated calcium channel protein Orai superfamily
UniProtKB:Q6TLE6 222
UniProtKB:A0A0R4I9A7 222
UniProtKB:B2GS90 222
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations