Gene
orai1b
- ID
- ZDB-GENE-050522-100
- Name
- ORAI calcium release-activated calcium modulator 1b
- Symbol
- orai1b Nomenclature History
- Previous Names
-
- orai1
- im:7146264
- zgc:109721
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable store-operated calcium channel activity. Acts upstream of or within sarcomere organization. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including head; heart; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146264 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Völkers et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 9 | Alliance | Immunodeficiency 9 | 612782 |
| tubular aggregate myopathy 2 | Alliance | Myopathy, tubular aggregate, 2 | 615883 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium release-activated calcium channel protein | Orai superfamily |
|---|---|---|---|
|
UniProtKB:A0A0R4I9A7
|
222 | ||
|
UniProtKB:Q6TLE6
|
222 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
orai1b-201
(1)
|
Ensembl | 1,299 nt |
Interactions and Pathways
No data available
Plasmids
No data available