Gene
orai1b
- ID
- ZDB-GENE-050522-100
- Name
- ORAI calcium release-activated calcium modulator 1b
- Symbol
- orai1b Nomenclature History
- Previous Names
-
- orai1
- im:7146264
- zgc:109721
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable store-operated calcium channel activity. Acts upstream of or within sarcomere organization. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including head; heart; liver; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 9 and tubular aggregate myopathy 2. Orthologous to human ORAI1 (ORAI calcium release-activated calcium modulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7146264 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Völkers et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-orai1b | N/A | Völkers et al., 2012 |
| MO2-orai1b | N/A | Völkers et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 9 | Alliance | Immunodeficiency 9 | 612782 |
| tubular aggregate myopathy 2 | Alliance | Myopathy, tubular aggregate, 2 | 615883 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium release-activated calcium channel protein | Orai superfamily |
|---|---|---|---|---|
| UniProtKB:A0A0R4I9A7 | InterPro | 222 | ||
| UniProtKB:Q6TLE6 | InterPro | 222 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
orai1b-201
(1)
|
Ensembl | 1,299 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-20G22 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7146264 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:109721 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192510 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205600 (1) | 1231 nt | ||
| Genomic | GenBank:CU928082 (1) | 85107 nt | ||
| Polypeptide | UniProtKB:A0A0R4I9A7 (1) | 222 aa |
- Gupta, R.K., Wasilewska, I., Palchevska, O., Kuźnicki, J. (2020) Knockout of stim2a Increases Calcium Oscillations in Neurons and Induces Hyperactive-Like Phenotype in Zebrafish Larvae. International Journal of Molecular Sciences. 21(17):
- Wasilewska, I., Gupta, R.K., Wojtaś, B., Palchevska, O., Kuźnicki, J. (2020) stim2b Knockout Induces Hyperactivity and Susceptibility to Seizures in Zebrafish Larvae. Cells. 9(5):
- Wasilewska, I., Gupta, R.K., Palchevska, O., Kuźnicki, J. (2019) Identification of Zebrafish Calcium Toolkit Genes and their Expression in the Brain. Genes. 10(3)
- Tse, M.K., Hung, T.S., Chan, C.M., Wong, T., Dorothea, M., Leclerc, C., Moreau, M., Miller, A.L., Webb, S.E. (2018) Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres.. Science China. Life sciences. 61(11):1352-1368
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Labonne, J.D., Lee, K.H., Iwase, S., Kong, I.K., Diamond, M.P., Layman, L.C., Kim, C.H., Kim, H.G. (2016) An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability. Human genetics. 135(7):757-71
- Völkers, M., Dolatabadi, N., Gude, N., Most, P., Sussman, M.A., and Hassel, D. (2012) Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish. Journal of Cell Science. 125(2):287-294
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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