Gene
abcg4a
- ID
- ZDB-GENE-050517-39
- Name
- ATP-binding cassette, sub-family G (WHITE), member 4a
- Symbol
- abcg4a Nomenclature History
- Previous Names
-
- abcg1a (1)
- abcg4
- si:ch211-117m20.3
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to localize to plasma membrane. Orthologous to human ABCG4 (ATP binding cassette subfamily G member 4).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la024956Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa17138 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33630 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa40464 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa40465 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017871 | ABC transporter-like, conserved site |
Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR013525 | ABC-2 type transporter, transmembrane domain |
Domain | IPR043926 | ABC transporter family G domain |
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Domain Details Per Protein
Protein | Length | AAA+ ATPase domain | ABC-2 type transporter, transmembrane domain | ABC transporter family G domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ATP-binding cassette subfamily G transporters | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|
UniProtKB:A2BFT1
|
641 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
abcg4a-202
(1)
|
Ensembl | 2,424 nt | ||
mRNA |
abcg4a-203
(1)
|
Ensembl | 1,926 nt | ||
ncRNA |
abcg4a-002
(1)
|
Ensembl | 500 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-117M20 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_682593 (1) | |||
Genomic | GenBank:BX294376 (1) | 178400 nt | ||
Polypeptide | UniProtKB:A2BFT1 (1) | 641 aa |
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Popovic, M., Zaja, R., Loncar, J., and Smital, T. (2010) A novel ABC transporter: The first insight into zebrafish (Danio rerio) Abch1. Marine Environmental Research. 69(S1):S11-S13
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Wang, S., Xu, P., Thorsen, J., Zhu, B., de Jong, P.J., Waldbieser, G., Kucuktas, H., and Liu, Z. (2007) Characterization of a BAC Library from Channel Catfish Ictalurus punctatus: Indications of High Levels of Chromosomal Reshuffling Among Teleost Genomes. Marine biotechnology (New York, N.Y.). 9(6):701-711
- Annilo, T., Chen, Z.Q., Shulenin, S., Costantino, J., Thomas, L., Lou, H., Stefanov, S., and Dean, M. (2006) Evolution of the vertebrate ABC gene family: Analysis of gene birth and death. Genomics. 88(1):1-11
- Dean, M., and Annilo, T. (2005) Evolution of the ATP-Binding Cassette (ABC) Transporter Superfamily in Vertebrates. Annual review of genomics and human genetics. 6:123-142
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