Gene
abcc3
- ID
- ZDB-GENE-050517-16
- Name
- ATP-binding cassette, sub-family C (CFTR/MRP), member 3
- Symbol
- abcc3 Nomenclature History
- Previous Names
-
- si:ch211-176g6.3
- si:ch73-359p15.1
- wu:fb94e12
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable ABC-type xenobiotic transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in endomembrane system and membrane. Predicted to be active in basolateral plasma membrane. Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017871 | ABC transporter-like, conserved site |
Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
Domain | IPR003593 | AAA+ ATPase domain |
Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
Domain | IPR056227 | ABC transporter, TMD0 domain |
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Domain Details Per Protein
Protein | Additional Resources | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter, TMD0 domain | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | ATP-binding cassette transporter C-like | Multi drug resistance-associated protein | P-loop containing nucleoside triphosphate hydrolase |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3AXY3 | InterPro | 1540 | |||||||||
UniProtKB:A0A8M3AY17 | InterPro | 1140 | |||||||||
UniProtKB:A0A8M3BDY5 | InterPro | 1107 | |||||||||
UniProtKB:A0A8M3B758 | InterPro | 1539 | |||||||||
UniProtKB:A0A8M3B4C9 | InterPro | 1539 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-359P15 | ZFIN Curated Data | |
Contained in | BAC | CH211-176G6 | ZFIN Curated Data | |
Encodes | EST | fb94e12 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_009306370 (1) | 6714 nt | ||
Genomic | GenBank:CT030207 (1) | 124665 nt | ||
Polypeptide | UniProtKB:A0A8M3AXY3 (1) | 1540 aa |
- Comparative Orthology
- Alliance
- Czimer, D., Porok, K., Csete, D., Gyüre, Z., Lavró, V., Fülöp, K., Chen, Z., Gyergyák, H., Tusnády, G.E., Burgess, S.M., Mócsai, A., Váradi, A., Varga, M. (2021) A New Zebrafish Model for Pseudoxanthoma Elasticum. Frontiers in cell and developmental biology. 9:628699
- Zhang, X., Xia, M., Su, X., Yuan, P., Li, X., Zhou, C., Wan, Z., Zou, W. (2021) Photolytic degradation elevated the toxicity of polylactic acid microplastics to developing zebrafish by triggering mitochondrial dysfunction and apoptosis. Journal of hazardous materials. 413:125321
- Moraes, J.S., da Silva Nornberg, B.F., Castro, M.R., Vaz, B.D.S., Mizuschima, C.W., Marins, L.F.F., Martins, C.M.G. (2020) Zebrafish (Danio rerio) ability to activate ABCC transporters after exposure to glyphosate and its formulation Roundup Transorb®. Chemosphere. 248:125959
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Mottaz, H., Schönenberger, R., Fischer, S., Eggen, R.I., Schirmer, K., Groh, K.J. (2017) Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish. Environmental pollution (Barking, Essex : 1987). 221:105-115
- Gistelinck, C., Gioia, R., Gagliardi, A., Tonelli, F., Marchese, L., Bianchi, L., Landi, C., Bini, L., Huysseune, A., Witten, P.E., Staes, A., Gevaert, K., De Rocker, N., Menten, B., Malfait, F., Leikin, S., Carra, S., Tenni, R., Rossi, A., De Paepe, A., Coucke, P., Willaert, A., Forlino, A. (2016) Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Scientific Reports. 6:21540
- Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436
- Xin, Q., Rotchell, J.M., Cheng, J., Yi, J., Zhang, Q. (2015) Silver nanoparticles affect the neural development of zebrafish embryos. Journal of applied toxicology : JAT. 35(12):1481-92
- Long, Y., Li, Q., Wang, Y., and Cui, Z. (2011) MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 153(3):310-317
- Annilo, T., Chen, Z.Q., Shulenin, S., Costantino, J., Thomas, L., Lou, H., Stefanov, S., and Dean, M. (2006) Evolution of the vertebrate ABC gene family: Analysis of gene birth and death. Genomics. 88(1):1-11
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