Gene

abcb11b

ID

ZDB-GENE-050517-14

Name

ATP-binding cassette, sub-family B (MDR/TAP), member 11b

Symbol

abcb11b Nomenclature History

Previous Names

bsep (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to have ATPase-coupled transmembrane transporter activity and canalicular bile acid transmembrane transporter activity. Involved in bile acid secretion. Predicted to localize to integral component of membrane. Used to study progressive familial intrahepatic cholestasis 2. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Is expressed in liver. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Ellis et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abcb11b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
benign recurrent intrahepatic cholestasis 2	Alliance	Cholestasis, benign recurrent intrahepatic, 2	605479
progressive familial intrahepatic cholestasis 2	Alliance	Cholestasis, progressive familial intrahepatic 2	601847

Associated With abcb11b Via Experimental Models

Human Disease	Fish	Conditions	Citations
progressive familial intrahepatic cholestasis 2	abcb11b^ci200/ci200	standard conditions	Ellis et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR011527	ABC transporter type 1, transmembrane domain
Family	IPR039421	Type 1 protein exporter
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036640	ABC transporter type 1, transmembrane domain superfamily

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	ABC transporter-like, ATP-binding domain	ABC transporter-like, conserved site	ABC transporter type 1, transmembrane domain	ABC transporter type 1, transmembrane domain superfamily	P-loop containing nucleoside triphosphate hydrolase	Type 1 protein exporter
UniProtKB:A0A8M1RNN7 InterPro	1348

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	abcb11b-201 (1) Ensembl	Ensembl	7,530 nt	Select Tool ZFIN BLAST
mRNA	abcb11b-202 (1) Ensembl	Ensembl	4,463 nt	Select Tool
mRNA	abcb11b-203 (1) Ensembl	Ensembl	7,443 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-abcb11	polyclonal	abcb11b		Rabbit	IHC	Kamiya Biomedical Company	18

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations