Gene

abcb11a

ID
ZDB-GENE-050517-13
Name
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
Symbol
abcb11a Nomenclature History
Previous Names
  • fc21d02
  • wu:fc21d02
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Is predicted to enable ABC-type bile acid transporter activity and canalicular bile acid transmembrane transporter activity. Involved in canalicular bile acid transport and transmembrane transport. Predicted to be located in membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Ellis et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With abcb11a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
benign recurrent intrahepatic cholestasis 2 Alliance Cholestasis, benign recurrent intrahepatic, 2 605479
progressive familial intrahepatic cholestasis 2 Alliance Cholestasis, progressive familial intrahepatic 2 601847
Associated With abcb11a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017871 ABC transporter, conserved site
Domain IPR003439 ABC transporter-like
Domain IPR003593 AAA+ ATPase domain
Domain IPR011527 ABC transporter type 1, transmembrane domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036640 ABC transporter type 1, transmembrane domain superfamily
Domain Details Per Protein
Protein Length AAA+ ATPase domain ABC transporter, conserved site ABC transporter-like ABC transporter type 1, transmembrane domain ABC transporter type 1, transmembrane domain superfamily P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F6NLY2 1277
UniProtKB:F1QSX6 1320
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations