Gene
sema3fa
- ID
- ZDB-GENE-050513-1
- Name
- sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
- Symbol
- sema3fa Nomenclature History
- Previous Names
-
- sema3f1 (1)
- wu:fb92d12
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables neuropilin binding activity. Acts upstream of or within neural crest cell migration and neutrophil clearance. Is expressed in brain; head; pectoral fin; and somite. Orthologous to human SEMA3F (semaphorin 3F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sema3fa | (6) | |
| CRISPR2-sema3fa | van der Klaauw et al., 2019 | |
| CRISPR3-sema3fa | van der Klaauw et al., 2019 | |
| CRISPR4-sema3fa | van der Klaauw et al., 2019 | |
| MO1-sema3fa | N/A | (3) |
| MO2-sema3fa | N/A | Tanaka et al., 2007 |
| TALEN1-sema3fa | Plant et al., 2020 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema3fa-201
(1)
|
Ensembl | 3,923 nt | ||
| mRNA |
sema3fa-202
(1)
|
Ensembl | 4,776 nt | ||
| mRNA |
sema3fa-203
(1)
|
Ensembl | 2,485 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-20F24 | ZFIN Curated Data | |
| Contains | SNP | rs3727987 | ||
| Contains | SNP | rs3727988 | ||
| Encodes | EST | fb92d12 | ZFIN Curated Data | |
| Encodes | cDNA | cssl:d409 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:195068 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195079 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001014822 (1) | 2391 nt | ||
| Genomic | GenBank:BX950172 (1) | 231139 nt | ||
| Polypeptide | RefSeq:NP_001014822 (1) | 796 aa |
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Nurcombe, Z.W., Hehr, C.L., McFarlane, S. (2023) Plexina4 and cell survival in the developing zebrafish hindbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(11):1323-1337
- Cheng, R.P., Dang, P., Taku, A.A., Moon, Y.J., Pham, V., Sun, X., Zhao, E., Raper, J.A. (2022) Loss of Neuropilin2a/b or Sema3fa alters olfactory sensory axon dynamics and protoglomerular targeting. Neural Development. 17:1
- Dang, P., Barnes, D.T., Cheng, R.P., Xu, A., Ji Moon, Y., Sripad Kodukula, S., Raper, J.A. (2022) Netrins and netrin receptors are essential for normal targeting of sensory axons in the zebrafish olfactory bulb. Neuroscience. 508:19-29
- Halabi, R., Cechmanek, P.B., Hehr, C.L., McFarlane, S. (2022) Semaphorin3f as a cardiomyocyte derived regulator of heart chamber development. Cell communication and signaling : CCS. 20:126
- Hehr, C.L., Halabi, R., McFarlane, S. (2022) Spatial regulation of amacrine cell genesis by Semaphorin 3f. Developmental Biology. 491:66-81
- Fazio, M., van Rooijen, E., Dang, M., van de Hoek, G., Ablain, J., Mito, J.K., Yang, S., Thomas, A., Michael, J., Fabo, T., Modhurima, R., Pessina, P., Kaufman, C.K., Zhou, Y., White, R.M., Zon, L.I. (2021) SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance. eLIFE. 10:
- Halabi, R., Watterston, C., Hehr, C.L., Mori-Kreiner, R., Childs, S.J., McFarlane, S. (2021) Semaphorin 3fa Controls Ocular Vascularization From the Embryo Through to the Adult. Investigative ophthalmology & visual science. 62:21
- Watterston, C., Halabi, R., McFarlane, S., Childs, S.J. (2021) Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting. PLoS Genetics. 17:e1009769
- Plant, T., Eamsamarng, S., Sanchez-Garcia, M.A., Reyes, L., Renshaw, S.A., Coelho, P., Mirchandani, A.S., Morgan, J.M., Ellett, F.E., Morrison, T., Humphries, D., Watts, E.R., Murphy, F., Raffo-Iraolagoitia, X.L., Zhang, A., Cash, J.L., Loynes, C., Elks, P.M., Van Eeden, F., Carlin, L.M., Furley, A.J.W., Whyte, M.K.B., Walmsley, S.R. (2020) Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. The Journal of Clinical Investigation. 130(6):3221-3237
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