Gene
cdc6
- ID
- ZDB-GENE-050506-131
- Name
- cell division cycle 6 homolog (S. cerevisiae)
- Symbol
- cdc6 Nomenclature History
- Previous Names
-
- im:7145727 (1)
- zgc:174506
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have DNA replication origin binding activity. Involved in mitotic cell cycle phase transition. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Is expressed in central nervous system and proliferative region. Orthologous to human CDC6 (cell division cycle 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145727 (12 images)
- IMAGE:7153999 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Yao et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 5 | Alliance | ?Meier-Gorlin syndrome 5 | 613805 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Meier-Gorlin syndrome | cdc6tsu21cd/tsu21cd | standard conditions | Yao et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR015163 | Cdc6, C-terminal |
| Domain | IPR054425 | Cdc6/ORC1-like, ATPase lid domain |
| Family | IPR016314 | Cell division protein Cdc6/18 |
| Family | IPR050311 | Origin Recognition Complex 1/Cell Division Control Protein 6 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ATPase, AAA-type, core | Cdc6, C-terminal | Cdc6/ORC1-like, ATPase lid domain | Cell division protein Cdc6/18 | Origin Recognition Complex 1/Cell Division Control Protein 6 | P-loop containing nucleoside triphosphate hydrolase | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8KC19
|
561 |
Interactions and Pathways
No data available
Plasmids
No data available