Gene
cdc6
- ID
- ZDB-GENE-050506-131
- Name
- cell division cycle 6 homolog (S. cerevisiae)
- Symbol
- cdc6 Nomenclature History
- Previous Names
-
- im:7145727 (1)
- zgc:174506
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable DNA replication origin binding activity. Acts upstream of or within mitotic cell cycle phase transition. Predicted to be active in nucleus. Is expressed in central nervous system and proliferative region. Used to study Meier-Gorlin syndrome. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145727 (12 images)
- IMAGE:7153999 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 7 figures from Yao et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdc6 | Yao et al., 2017 | |
| MO1-cdc6 | N/A | Yao et al., 2017 |
| MO2-cdc6 | N/A | Yao et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Meier-Gorlin syndrome 5 | Alliance | Meier-Gorlin syndrome 5 | 613805 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Meier-Gorlin syndrome | cdc6tsu21cd/tsu21cd | standard conditions | Yao et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR003959 | ATPase, AAA-type, core |
| Domain | IPR015163 | Cdc6, C-terminal |
| Domain | IPR054425 | Cdc6/ORC1-like, ATPase lid domain |
| Family | IPR016314 | Cell division protein Cdc6/18 |
| Family | IPR050311 | Origin Recognition Complex 1/Cell Division Control Protein 6 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ATPase, AAA-type, core | Cdc6, C-terminal | Cdc6/ORC1-like, ATPase lid domain | Cell division protein Cdc6/18 | Origin Recognition Complex 1/Cell Division Control Protein 6 | P-loop containing nucleoside triphosphate hydrolase | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8KC19 | InterPro | 561 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-8O15 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7145727 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7153999 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:174506 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001127333 (1) | 2165 nt | ||
| Genomic | GenBank:CR848705 (2) | 259070 nt | ||
| Polypeptide | UniProtKB:A8KC19 (1) | 561 aa |
- Madakashira, B.P., Magnani, E., Ranjan, S., Sadler, K.C. (2024) DNA hypomethylation activates Cdk4/6 and Atr to induce DNA replication and cell cycle arrest to constrain liver outgrowth in zebrafish. Nucleic acids research. 52(6):3069-3087
- Li, L., Tai, Z., Liu, W., Luo, Y., Wu, Y., Lin, S., Liu, M., Gao, B., Liu, J.X. (2023) Copper overload impairs hematopoietic stem and progenitor cell proliferation via prompting HSF1/SP1 aggregation and the subsequently downregulating FOXM1-Cytoskeleton axis. iScience. 26:106406106406
- Wang, C., Chen, X., Dai, Y., Zhang, Y., Sun, Y., Cui, X. (2022) Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. BMC genomic data. 23:39
- Wagner, D.E., Weinreb, C., Collins, Z.M., Briggs, J.A., Megason, S.G., Klein, A.M. (2018) Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science (New York, N.Y.). 360(6392):981-987
- Yao, L., Chen, J., Wu, X., Jia, S., Meng, A. (2017) Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Human molecular genetics. 26(21):4168-4180
- Yuan, B., Wang, X., Fan, C., You, J., Liu, Y., Weber, J.D., Zhong, H., Zhang, Y. (2016) DHX33 transcriptionally controls genes involved in cell cycle. Molecular and cellular biology. 36(23):2903-2917
- Jacob, V., Chernyavskaya, Y., Chen, X., Tan, P.S., Kent, B., Hoshida, Y., Sadler, K.C. (2015) DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development (Cambridge, England). 142(3):510-21
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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