Gene
hmgb3a
- ID
- ZDB-GENE-050428-1
- Name
- high mobility group box 3a
- Symbol
- hmgb3a Nomenclature History
- Previous Names
-
- wu:fb17a03
- wu:fk52f12
- zgc:162415
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity, bending and transcription factor binding activity. Predicted to be involved in several processes, including chromatin remodeling; positive regulation of innate immune response; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nuclear chromatin. Human ortholog(s) of this gene implicated in syndromic microphthalmia. Is expressed in several structures, including axis; intermediate cell mass of mesoderm; mesoderm; nervous system; and pectoral fin bud. Orthologous to human HMGB3 (high mobility group box 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7156270 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic microphthalmia 13 | Alliance | ?Microphthalmia, syndromic 13 | 300915 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | High mobility group box domain | High mobility group box domain superfamily | High Mobility Group Box (HMGB) |
|---|---|---|---|---|
|
UniProtKB:F1QGP8
|
213 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
hmgb3a-201
(1)
|
Ensembl | 589 nt | ||
| mRNA |
hmgb3a-202
(1)
|
Ensembl | 1,709 nt | ||
| mRNA |
hmgb3a-204
(1)
|
Ensembl | 837 nt | ||
| ncRNA |
hmgb3a-002
(1)
|
Ensembl | 675 nt |
Interactions and Pathways
No data available
Plasmids
No data available