sipa1l3

ID

ZDB-GENE-050420-109

Name

signal-induced proliferation-associated 1 like 3

Symbol

sipa1l3 Nomenclature History

Previous Names

si:dkey-149j18.1 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable GTPase activator activity. Acts upstream of or within lens development in camera-type eye. Predicted to be active in Golgi apparatus and plasma membrane. Is expressed in lens and solid lens vesicle. Used to study cataract. Human ortholog(s) of this gene implicated in cataract 45. Orthologous to human SIPA1L3 (signal induced proliferation associated 1 like 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Greenlees et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Greenlees et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sipa1l3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cataract 45	Alliance	?Cataract 45	616851

Associated With sipa1l3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	WT + MO2-sipa1l3	standard conditions	Greenlees et al., 2015
cataract	WT + MO1-sipa1l3	standard conditions	Greenlees et al., 2015

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000331	Rap/Ran-GAP domain
Domain	IPR001478	PDZ domain
Domain	IPR021818	Signal-induced proliferation-associated 1-like protein, C-terminal
Family	IPR050989	Rap1/Ran GTPase-activating
Homologous_superfamily	IPR035974	Rap/Ran-GAP superfamily
Homologous_superfamily	IPR036034	PDZ superfamily