Gene

dctn1b

ID
ZDB-GENE-050419-28
Name
dynactin 1b
Symbol
dctn1b Nomenclature History
Previous Names
  • mok2 (1)
  • si:ch211-132e22.1
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Is predicted to enable microtubule plus-end binding activity. Involved in cytoplasmic microtubule organization; establishment of mitotic spindle orientation; and nuclear migration. Acts upstream of or within camera-type eye photoreceptor cell differentiation. Predicted to be located in cytoskeleton. Predicted to be part of microtubule associated complex. Is expressed in nervous system and trunk. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Atkins et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dctn1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 1 Alliance {Amyotrophic lateral sclerosis, susceptibility to} 105400
distal hereditary motor neuronopathy type 7B Alliance Neuronopathy, distal hereditary motor, type VIIB 607641
Perry syndrome Alliance Perry syndrome 168605
Associated With dctn1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000938 CAP Gly-rich domain
Domain IPR022157 Dynein associated protein
Homologous_superfamily IPR036859 CAP Gly-rich domain superfamily
Domain Details Per Protein
Protein Length CAP Gly-rich domain CAP Gly-rich domain superfamily Dynein associated protein
UniProtKB:F6PC33 1258
UniProtKB:A5Z214 222
UniProtKB:A0A0R4IW36 1195
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations