ZFIN is now using GRCz12tu for Genomic Data
Gene
dctn1b
- ID
- ZDB-GENE-050419-28
- Name
- dynactin 1b
- Symbol
- dctn1b Nomenclature History
- Previous Names
-
- mok2 (1)
- si:ch211-132e22.1
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Acts upstream of or within camera-type eye photoreceptor cell differentiation. Predicted to be located in cell cortex and cytoskeleton. Predicted to be part of microtubule associated complex. Predicted to be active in axon; kinetochore; and spindle pole. Is expressed in nervous system and trunk. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Atkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 1 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to} | 105400 |
| autosomal dominant distal hereditary motor neuronopathy 14 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 14 | 607641 |
| Perry syndrome | Alliance | Perry syndrome | 168605 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Dynein associated protein |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9QK32 | InterPro | 1257 | |||
| UniProtKB:A0A8M3BEJ1 | InterPro | 1260 | |||
| UniProtKB:A0A8M3AYX5 | InterPro | 1258 | |||
| UniProtKB:A0A8M9QNN7 | InterPro | 1263 | |||
| UniProtKB:A0A8M3B7W5 | InterPro | 1251 | |||
| UniProtKB:A0A8M9QFT7 | InterPro | 1264 | |||
| UniProtKB:A0A8M3B541 | InterPro | 1245 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dctn1b-201
(1)
|
Ensembl | 8,610 nt | ||
| mRNA |
dctn1b-202
(1)
|
Ensembl | 3,588 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers