Gene
dctn1b
- ID
- ZDB-GENE-050419-28
- Name
- dynactin 1b
- Symbol
- dctn1b Nomenclature History
- Previous Names
-
- mok2 (1)
- si:ch211-132e22.1
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Acts upstream of or within camera-type eye photoreceptor cell differentiation. Predicted to be located in cell cortex and cytoskeleton. Predicted to be part of microtubule associated complex. Predicted to be active in axon; kinetochore; and spindle pole. Is expressed in nervous system and trunk. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Orthologous to human DCTN1 (dynactin subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Atkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dctn1b | Drerup et al., 2017 | |
| CRISPR2-dctn1b | Atkins et al., 2019 | |
| MO1-dctn1b | N/A | Insinna et al., 2010 |
| MO2-dctn1b | N/A | Insinna et al., 2010 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 1 | Alliance | {Amyotrophic lateral sclerosis, susceptibility to} | 105400 |
| autosomal dominant distal hereditary motor neuronopathy 14 | Alliance | Neuronopathy, distal hereditary motor, autosomal dominant 14 | 607641 |
| Perry syndrome | Alliance | Perry syndrome | 168605 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Dynein associated protein |
|---|---|---|---|---|
|
UniProtKB:A0A8M9QK32
|
1257 | |||
|
UniProtKB:A0A8M3BEJ1
|
1260 | |||
|
UniProtKB:A0A8M3AYX5
|
1258 | |||
|
UniProtKB:A0A8M9QNN7
|
1263 | |||
|
UniProtKB:A0A8M3B7W5
|
1251 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dctn1b-201
(1)
|
Ensembl | 8,610 nt | ||
| mRNA |
dctn1b-202
(1)
|
Ensembl | 3,588 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-132E22 | ZFIN Curated Data | |
| Contained in | BAC | CH211-195E19 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021480759 (1) | 8702 nt | ||
| Genomic | GenBank:CR559945 (1) | 186151 nt | ||
| Polypeptide | UniProtKB:A0A8M9QFT7 (1) | 1264 aa |
- Nam, M.K., Moon, J.M., Kim, G.Y., Min Kim, S., Rhim, H. (2022) The Novel Human HtrA2 Ortholog in Zebrafish: New Molecular Insight and Challenges into the Imbalance of Homeostasis. Gene. 819:146263
- Atkins, M., Gasmi, L., Bercier, V., Revenu, C., Del Bene, F., Hazan, J., Fassier, C. (2019) FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation. The Journal of cell biology. 218(10):3290-3306
- Bercier, V., Hubbard, J.M., Fidelin, K., Duroure, K., Auer, T.O., Revenu, C., Wyart, C., Del Bene, F. (2019) Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities. Molecular neurodegeneration. 14:27
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Drerup, C.M., Herbert, A.L., Monk, K.R., Nechiporuk, A.V. (2017) Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Insinna, C., Baye, L.M., Amsterdam, A., Besharse, J.C., and Link, B.A. (2010) Analysis of a zebrafish dync1h1 mutant reveals multiple functions for cytoplasmic dynein 1 during retinal photoreceptor development. Neural Development. 5:12
- Tsujikawa, M., Omori, Y., Biyanwila, J., and Malicki, J. (2007) Mechanism of positioning the cell nucleus in vertebrate photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 104(37):14819-14824
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