Gene

chd2

ID
ZDB-GENE-050419-256
Name
chromodomain helicase DNA binding protein 2
Symbol
chd2 Nomenclature History
Previous Names
  • si:ch211-196l7.5
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and DNA helicase activity. Involved in chordate embryonic development and locomotion. Predicted to localize to nucleus. Used to study childhood onset epileptic encephalopathy. Human ortholog(s) of this gene implicated in childhood onset epileptic encephalopathy. Orthologous to human CHD2 (chromodomain helicase DNA binding protein 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chd2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
childhood onset epileptic encephalopathy Alliance Develomental and epileptic encephalopathy 94 615369
Associated With chd2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023779 Chromo domain, conserved site
Domain IPR000330 SNF2-related domain
Domain IPR000953 Chromo/chromo shadow domain
Domain IPR001650 Helicase, C-terminal
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR023780 Chromo domain
Domain IPR025260 Domain of unknown function DUF4208
Domain IPR040793 CDH1/2, SANT-Helical linker 1
Homologous_superfamily IPR016197 Chromo-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR038718 SNF2-like, N-terminal domain superfamily
Domain Details Per Protein
Protein Length CDH1/2, SANT-Helical linker 1 Chromo/chromo shadow domain Chromo domain Chromo domain, conserved site Chromo-like domain superfamily Domain of unknown function DUF4208 Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase SNF2-like, N-terminal domain superfamily SNF2-related domain
UniProtKB:Q1LVN0 1694
UniProtKB:A0A0R4IR86 1799
UniProtKB:F1QRB9 148
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations