Gene
ddb2
- ID
- ZDB-GENE-050419-169
- Name
- damage-specific DNA binding protein 2
- Symbol
- ddb2 Nomenclature History
- Previous Names
-
- si:dkey-45f10.3
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA binding activity. Predicted to contribute to damaged DNA binding activity. Predicted to be involved in nucleotide-excision repair and response to UV. Predicted to act upstream of or within DNA damage response. Predicted to be located in chromosome. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus and site of DNA damage. Is expressed in central nervous system and neurons. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group E. Orthologous to human DDB2 (damage specific DNA binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7165203 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| xeroderma pigmentosum group E | Alliance | Xeroderma pigmentosum, group E, DDB-negative subtype | 278740 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Family | IPR033312 | DNA damage-binding protein 2 |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
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Domain Details Per Protein
| Protein | Additional Resources | Length | DNA damage-binding protein 2 | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PLU3 | InterPro | 280 | |||||
| UniProtKB:A0A8M2B5I0 | InterPro | 351 | |||||
| UniProtKB:Q2YDS1 | InterPro PDB | 496 | |||||
| UniProtKB:Z4YI04 | InterPro | 497 | |||||
| UniProtKB:A0A8M2B5L4 | InterPro | 503 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-45F10 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7165203 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083061 (1) | 1805 nt | ||
| Genomic | GenBank:BX942814 (2) | 106289 nt | ||
| Polypeptide | UniProtKB:A0A8M2B5L4 (1) | 503 aa |
- Shi, W.J., Long, X.B., Li, S.Y., Ma, D.D., Liu, F., Zhang, J.G., Lu, Z.J., Ying, G.G. (2022) Dydrogesterone and levonorgestrel at environmentally relevant concentrations have antagonist effects with rhythmic oscillation in brain and eyes of zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 248:106177
- Zada, D., Sela, Y., Matosevich, N., Monsonego, A., Lerer-Goldshtein, T., Nir, Y., Appelbaum, L. (2021) Parp1 promotes sleep, which enhances DNA repair in neurons. Molecular Cell. 81(24):4979-4993.e7
- Zhao, H., Li, H., Du, J., Di Mauro, G., Lungu-Mitea, S., Geyer, N., Vallone, D., Bertolucci, C., Foulkes, N.S. (2021) Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair. PLoS Genetics. 17:e1009356
- Costa, S.R., Velasques, R.R., Hoff, M.L.M., Souza, M.M., Sandrini, J.Z. (2019) Characterization of different DNA repair pathways in hepatic cells of Zebrafish (Danio rerio). DNA repair. 83:102695
- Arcanjo, C., Armant, O., Floriani, M., Cavalie, I., Camilleri, V., Simon, O., Orjollet, D., Adam-Guillermin, C., Gagnaire, B. (2018) Tritiated water exposure disrupts myofibril structure and induces mis-regulation of eye opacity and DNA repair genes in zebrafish early life stages. Aquatic toxicology (Amsterdam, Netherlands). 200:114-126
- Komoike, Y., Matsuoka, M. (2018) In vitro and in vivo studies of oxidative stress responses against acrylamide toxicity in zebrafish. Journal of hazardous materials. 365:430-439
- Shi, W.J., Jiang, Y.X., Huang, G.Y., Zhao, J.L., Zhang, J.N., Liu, Y.S., Xie, L., Ying, G.G. (2018) Dydrogesterone causes male bias and accelerates sperm maturation in zebrafish (Danio rerio). Environmental science & technology. 52(15):8903-8911
- Chang, Y., Lee, W.Y., Lin, Y.J., Hsu, T. (2017) Mercury (II) impairs nucleotide excision repair (NER) in zebrafish (Danio rerio) embryos by targeting primarily at the stage of DNA incision. Aquatic toxicology (Amsterdam, Netherlands). 192:97-104
- Chen, Q., Li, C., Gong, Z., Chan, E.C., Snyder, S.A., Lam, S.H. (2017) Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 172:429-439
- Ling, L.B., Chang, Y., Liu, C.W., Lai, P.L., Hsu, T. (2017) Oxidative stress intensity-related effects of cadmium (Cd) and paraquat (PQ) on UV-damaged-DNA binding and excision repair activities in zebrafish (Danio rerio) embryos. Chemosphere. 167:10-18
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