Gene

tnni2b.1

ID
ZDB-GENE-050417-49
Name
troponin I type 2b (skeletal, fast), tandem duplicate 1
Symbol
tnni2b.1 Nomenclature History
Previous Names
  • tropI-2a (1)
  • zgc:110715
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to localize to troponin complex. Human ortholog(s) of this gene implicated in distal arthrogryposis type 2B1 and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnni2b.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
distal arthrogryposis Alliance Arthrogryposis, distal, type 2B1 601680
distal arthrogryposis type 2B1 Alliance Arthrogryposis, distal, type 2B1 601680
Associated With tnni2b.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001978 Troponin
Homologous_superfamily IPR038077 Troponin domain superfamily
Domain Details Per Protein
Protein Length Troponin Troponin domain superfamily
UniProtKB:F1QCC0 176
UniProtKB:Q567W1 176
UniProtKB:E9QCC3 133
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
tnni2b.1 and tnni2b.2 form a cluster on chromosome 7 and are likely the result of a tandem duplication. The location of the cluster in zebrafish as well as the amino acid identity of both genes support orthology to human TNNI2 and mouse Tnni2.
Citations