Gene
chrna5
- ID
- ZDB-GENE-050417-440
- Name
- cholinergic receptor, nicotinic, alpha 5
- Symbol
- chrna5 Nomenclature History
- Previous Names
-
- zgc:110642
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity. Predicted to be involved in several processes, including presynaptic modulation of chemical synaptic transmission; response to nicotine; and synaptic signaling. Predicted to act upstream of or within monoatomic ion transport. Predicted to be located in postsynaptic membrane. Predicted to be part of acetylcholine-gated channel complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in interpeduncular nucleus tegmentum and liver. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cocaine abuse; esophagus squamous cell carcinoma; nicotine dependence; and respiratory system cancer (multiple). Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| a250 | Allele with multiple variants | Unknown | Unknown | CRISPR | |
| la020436Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la027957Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa367 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23361 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45648 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-chrna5 | Thyme et al., 2019 | |
| CRISPR2-chrna5 | Thyme et al., 2019 | |
| CRISPR3-chrna5 | Thyme et al., 2019 | |
| CRISPR4-chrna5 | Thyme et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
| Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
| Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
| Family | IPR002394 | Nicotinic acetylcholine receptor |
| Family | IPR006201 | Neurotransmitter-gated ion-channel |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily | Nicotinic acetylcholine receptor |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q567Y7 | InterPro | 466 | ||||||||
| UniProtKB:A0A8M9P128 | InterPro | 439 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chrna5-201
(1)
|
Ensembl | 1,752 nt | ||
| mRNA |
chrna5-202
(1)
|
Ensembl | 1,440 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-235D11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110642 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191387 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017885 (1) | 1740 nt | ||
| Genomic | GenBank:CT027604 (2) | 64306 nt | ||
| Polypeptide | UniProtKB:Q567Y7 (1) | 466 aa |
- Kumari, S., Dhiman, P., Kumar, R., Rahmatkar, S.N., Singh, D. (2022) Chemo-kindling in adult zebrafish alters spatial cognitive functions but not social novelty recognition. Behavioural brain research. 438:114158
- García-González, J., Brock, A.J., Parker, M.O., Riley, R.J., Joliffe, D., Sudwarts, A., Teh, M.T., Busch-Nentwich, E.M., Stemple, D.L., Martineau, A.R., Kaprio, J., Palviainen, T., Kuan, V., Walton, R.T., Brennan, C.H. (2020) Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. eLIFE. 9:
- Pedersen, J.E., Bergqvist, C.A., Larhammar, D. (2019) Evolution of vertebrate nicotinic acetylcholine receptors. BMC Evolutionary Biology. 19:38
- Thyme, S.B., Pieper, L.M., Li, E.H., Pandey, S., Wang, Y., Morris, N.S., Sha, C., Choi, J.W., Herrera, K.J., Soucy, E.R., Zimmerman, S., Randlett, O., Greenwood, J., McCarroll, S.A., Schier, A.F. (2019) Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Cell. 177(2):478-491.e20
- Parker, M.O., Evans, A.M., Brock, A.J., Combe, F.J., Teh, M.T., Brennan, C.H. (2016) Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood. Addiction biology. 21(1):49-60
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Parker, M.O., Brock, A.J., Sudwarts, A., Teh, M.T., Combe, F.J., Brennan, C.H. (2015) Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers in behavioral neuroscience. 9:271
- Menelaou, E., Udvadia, A.J., Tanguay, R.L., Svoboda, K.R. (2014) Activation of α2A-containing nicotinic acetylcholine receptors mediates nicotine-induced motor output in embryonic zebrafish. The European journal of neuroscience. 40(1):2225-2240
- See, K., Yadav, P., Giegerich, M., Cheong, P.S., Graf, M., Vyas, H., Lee, S.G., Mathavan, S., Fischer, U., Sendtner, M., and Winkler, C. (2014) SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. Human molecular genetics. 23(7):1754-70
- Hong, E., Santhakumar, K., Akitake, C.A., Ahn, S.J., Thisse, C., Thisse, B., Wyart, C., Mangin, J.M., and Halpern, M.E. (2013) Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proceedings of the National Academy of Sciences of the United States of America. 110(52):21171-21176
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