Gene
chrna5
- ID
- ZDB-GENE-050417-440
- Name
- cholinergic receptor, nicotinic, alpha 5
- Symbol
- chrna5 Nomenclature History
- Previous Names
-
- zgc:110642
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to contribute to acetylcholine binding activity and acetylcholine receptor activity. Predicted to be involved in several processes, including chemical synaptic transmission; regulation of membrane potential; and response to nicotine. Predicted to localize to acetylcholine-gated channel complex; neuron projection; and synapse. Human ortholog(s) of this gene implicated in lung cancer. Is expressed in interpeduncular nucleus tegmentum and liver. Orthologous to human CHRNA5 (cholinergic receptor nicotinic alpha 5 subunit).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018000 | Neurotransmitter-gated ion-channel, conserved site |
Domain | IPR006029 | Neurotransmitter-gated ion-channel transmembrane domain |
Domain | IPR006202 | Neurotransmitter-gated ion-channel ligand-binding domain |
Family | IPR002394 | Nicotinic acetylcholine receptor |
Family | IPR006201 | Neurotransmitter-gated ion-channel |
Homologous_superfamily | IPR036719 | Neurotransmitter-gated ion-channel transmembrane domain superfamily |
Homologous_superfamily | IPR036734 | Neurotransmitter-gated ion-channel ligand-binding domain superfamily |
Homologous_superfamily | IPR038050 | Neuronal acetylcholine receptor |
Domain Details Per Protein
Protein | Length | Neuronal acetylcholine receptor | Neurotransmitter-gated ion-channel | Neurotransmitter-gated ion-channel, conserved site | Neurotransmitter-gated ion-channel ligand-binding domain | Neurotransmitter-gated ion-channel ligand-binding domain superfamily | Neurotransmitter-gated ion-channel transmembrane domain | Neurotransmitter-gated ion-channel transmembrane domain superfamily | Nicotinic acetylcholine receptor |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q567Y7
|
466 | ||||||||
UniProtKB:A0A8M9P128
|
439 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
chrna5-201
(1)
|
Ensembl | 1,752 nt | ||
mRNA |
chrna5-202
(1)
|
Ensembl | 1,440 nt |
Interactions and Pathways
No data available
Plasmids
No data available