Gene
mecr
- ID
- ZDB-GENE-050417-399
- Name
- mitochondrial trans-2-enoyl-CoA reductase
- Symbol
- mecr Nomenclature History
- Previous Names
-
- zgc:110153 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7156062 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| childhood-onset dystonia with optic atrophy and basal ganglia abnormalities | Alliance | Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities | 617282 |
| Optic atrophy 16 | 620629 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR013149 | Alcohol dehydrogenase-like, C-terminal |
| Domain | IPR013154 | Alcohol dehydrogenase-like, N-terminal |
| Domain | IPR020843 | Polyketide synthase, enoylreductase domain |
| Family | IPR051034 | Mitochondrial Enoyl-ACP Reductase |
| Homologous_superfamily | IPR011032 | GroES-like superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alcohol dehydrogenase-like, C-terminal | Alcohol dehydrogenase-like, N-terminal | GroES-like superfamily | Mitochondrial Enoyl-ACP Reductase | NAD(P)-binding domain superfamily | Polyketide synthase, enoylreductase domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P7W8
|
190 | ||||||
|
UniProtKB:Q6GQN8
|
377 | ||||||
|
UniProtKB:Q568Q9
|
377 | ||||||
|
UniProtKB:A0A8M9NZ96
|
263 |
Interactions and Pathways
No data available
Plasmids
No data available