Gene
tfap2b
- ID
- ZDB-GENE-050417-394
- Name
- transcription factor AP-2 beta
- Symbol
- tfap2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cartilage development. Predicted to be active in nucleus. Is expressed in several structures, including basal plate midbrain region; nervous system; pharyngeal arch; pronephros; and ventral mesoderm. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Orthologous to human TFAP2B (transcription factor AP-2 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110163 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zada et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Char syndrome | Alliance | Char syndrome | 169100 |
| Patent ductus arteriosus 2 | 617035 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Transcription factor AP-2 | Transcription factor AP-2 beta | Transcription factor AP-2, C-terminal |
|---|---|---|---|---|
|
UniProtKB:Q4TTV4
|
439 | |||
|
UniProtKB:A0A8M2B7U7
|
457 | |||
|
UniProtKB:Q561Y4
|
266 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tfap2b-201
(1)
|
Ensembl | 4,999 nt |
Interactions and Pathways
No data available
Plasmids
No data available