rrp7a

ID

ZDB-GENE-050417-38

Name

ribosomal RNA processing 7 homolog A

Symbol

rrp7a Nomenclature History

Previous Names

zgc:110084

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable RNA binding activity. Acts upstream of or within head development and regulation of rRNA processing. Predicted to be part of CURI complex and UTP-C complex. Is expressed in brain; eye; and head. Used to study primary microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 28. Orthologous to several human genes including RRP7A (ribosomal RNA processing 7 homolog A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110084 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Farooq et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rrp7a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal recessive microcephaly 28	Alliance	?Microcephaly 28, primary, autosomal recessive	619453

Associated With rrp7a Via Experimental Models

Human Disease	Fish	Conditions	Citations
primary microcephaly	rrp7a^{sa11429/sa11429} (AB/TL)	standard conditions	Farooq et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR024326	Ribosomal RNA-processing protein 7, C-terminal domain
Domain	IPR034890	Rrp7A, RNA recognition motif
Family	IPR040446	Ribosomal RNA-processing protein 7
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily