ZFIN is now using GRCz12tu for Genomic Data
Gene
nfu1
- ID
- ZDB-GENE-050417-365
- Name
- NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
- Symbol
- nfu1 Nomenclature History
- Previous Names
-
- HIRA interacting protein 5
- hirip5 (1)
- zgc:109711
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in protein maturation. Predicted to act upstream of or within iron-sulfur cluster assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109711 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 93 | Alliance | Spastic paraplegia 93, autosomal recessive | 620938 |
| multiple mitochondrial dysfunctions syndrome 1 | Alliance | Multiple mitochondrial dysfunctions syndrome 1 | 605711 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001075 | NIF system FeS cluster assembly, NifU, C-terminal |
| Domain | IPR014824 | Scaffold protein Nfu/NifU, N-terminal |
| Family | IPR035433 | NFU1-like |
| Homologous_superfamily | IPR034904 | Fe-S cluster assembly domain superfamily |
| Homologous_superfamily | IPR036498 | Scaffold protein Nfu/NifU, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fe-S cluster assembly domain superfamily | NFU1-like | NIF system FeS cluster assembly, NifU, C-terminal | Scaffold protein Nfu/NifU, N-terminal | Scaffold protein Nfu/NifU, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:B0S8L0 | InterPro | 243 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers