ZFIN is now using GRCz12tu for Genomic Data
Gene
nfu1
- ID
- ZDB-GENE-050417-365
- Name
- NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
- Symbol
- nfu1 Nomenclature History
- Previous Names
-
- HIRA interacting protein 5
- hirip5 (1)
- zgc:109711
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in protein maturation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 93 and multiple mitochondrial dysfunctions syndrome 1. Orthologous to human NFU1 (NFU1 iron-sulfur cluster scaffold).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109711 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 93 | Alliance | Spastic paraplegia 93, autosomal recessive | 620938 |
| multiple mitochondrial dysfunctions syndrome 1 | Alliance | Multiple mitochondrial dysfunctions syndrome 1 | 605711 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001075 | NIF system FeS cluster assembly, NifU, C-terminal |
| Domain | IPR014824 | Scaffold protein Nfu/NifU, N-terminal |
| Family | IPR035433 | NFU1-like |
| Homologous_superfamily | IPR034904 | Fe-S cluster assembly domain superfamily |
| Homologous_superfamily | IPR036498 | Scaffold protein Nfu/NifU, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fe-S cluster assembly domain superfamily | NFU1-like | NIF system FeS cluster assembly, NifU, C-terminal | Scaffold protein Nfu/NifU, N-terminal | Scaffold protein Nfu/NifU, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:B0S8L0 | InterPro | 243 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers