Gene
tmco1
- ID
- ZDB-GENE-050417-344
- Name
- transmembrane and coiled-coil domains 1
- Symbol
- tmco1 Nomenclature History
- Previous Names
-
- sb:cb729
- zgc:110322
- zgc:92740
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have calcium channel activity. Involved in calcium ion transmembrane transport and endoplasmic reticulum calcium ion homeostasis. Predicted to localize to endoplasmic reticulum and integral component of endoplasmic reticulum membrane. Is expressed in several structures, including axis; hatching gland; lens; polster; and solid lens vesicle. Orthologous to human TMCO1 (transmembrane and coiled-coil domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb729 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1 | Alliance | Craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development 1 | 213980 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium load-activated calcium channel | Integral membrane protein EMC3/TMCO1-like |
|---|---|---|---|
|
UniProtKB:Q6DGW9
|
188 |
Interactions and Pathways
No data available
Plasmids
No data available