Gene
tmco1
- ID
- ZDB-GENE-050417-344
- Name
- transmembrane and coiled-coil domains 1
- Symbol
- tmco1 Nomenclature History
- Previous Names
-
- sb:cb729
- zgc:110322
- zgc:92740
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable calcium channel activity and ribosome binding activity. Involved in calcium ion transmembrane transport and endoplasmic reticulum calcium ion homeostasis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including axis; hatching gland; lens; polster; and solid lens vesicle. Human ortholog(s) of this gene implicated in craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1. Orthologous to human TMCO1 (transmembrane and coiled-coil domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb729 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa11208 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 1 | Alliance | Craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development 1 | 213980 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calcium load-activated calcium channel | Integral membrane protein EMC3/TMCO1-like |
|---|---|---|---|---|
| UniProtKB:Q6DGW9 | InterPro | 188 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-216K22 | ZFIN Curated Data | |
| Encodes | EST | cb729 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:92740 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110322 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173840 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174746 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192149 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002575 (1) | 1141 nt | ||
| Genomic | GenBank:BX927144 (1) | 168503 nt | ||
| Polypeptide | UniProtKB:Q6DGW9 (1) | 188 aa |
- Zhai, W., Wang, Z., Ye, C., Ke, L., Wang, H., Liu, H. (2023) IL-6 Mutation Attenuates Liver Injury Caused by Aeromonas hydrophila Infection by Reducing Oxidative Stress in Zebrafish. International Journal of Molecular Sciences. 24(24):
- Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wang, Q.C., Zheng, Q., Tan, H., Zhang, B., Li, X., Yang, Y., Yu, J., Liu, Y., Chai, H., Wang, X., Sun, Z., Wang, J.Q., Zhu, S., Wang, F., Yang, M., Guo, C., Wang, H., Zheng, Q., Li, Y., Chen, Q., Zhou, A., Tang, T.S. (2016) TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel.. Cell. 165(6):1454-66
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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