Gene

arhgap1

ID

ZDB-GENE-050417-305

Name

Rho GTPase activating protein 1

Symbol

arhgap1 Nomenclature History

Previous Names

fk03b12
fk61c06
wu:cegs2891
wu:fk03b12
wu:fk61c06
zgc:110361

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of endocytic recycling and small GTPase mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm. Is expressed in female organism; musculature system; nervous system; and somite. Orthologous to human ARHGAP1 (Rho GTPase activating protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110361 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgap1 Human Ortholog

No data available

Associated With arhgap1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000198	Rho GTPase-activating protein domain
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR049592	Rho GTPase-activating protein 1, RhoGAP domain
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR036865	CRAL-TRIO lipid binding domain superfamily

Domain Details Per Protein

Protein	Length	CRAL-TRIO lipid binding domain	CRAL-TRIO lipid binding domain superfamily	Rho GTPase-activating protein 1, RhoGAP domain	Rho GTPase-activating protein domain	Rho GTPase activation protein
UniProtKB:Q568D8 InterPro	434

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgap1-201 (1) Ensembl	Ensembl	3,653 nt	Select Tool ZFIN BLAST
mRNA	arhgap1-203 (1) Ensembl	Ensembl	1,306 nt	Select Tool ZFIN BLAST
ncRNA	arhgap1-002 (1) Ensembl	Ensembl	440 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations