Gene
hmgb3b
- ID
- ZDB-GENE-050417-290
- Name
- high mobility group box 3b
- Symbol
- hmgb3b Nomenclature History
- Previous Names
-
- fa19b06
- fj43d02
- wu:fa19b06
- wu:fj43d02
- zgc:112073
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity, bending and transcription factor binding activity. Predicted to be involved in several processes, including chromatin remodeling; positive regulation of innate immune response; and positive regulation of transcription by RNA polymerase II. Predicted to localize to cytoplasm and nuclear chromatin. Human ortholog(s) of this gene implicated in syndromic microphthalmia. Is expressed in central nervous system; intermediate cell mass of mesoderm; ovary; and pectoral fin bud. Orthologous to human HMGB3 (high mobility group box 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909793 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic microphthalmia 13 | Alliance | ?Microphthalmia, syndromic 13 | 300915 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | High mobility group box domain | High mobility group box domain superfamily | High Mobility Group Box (HMGB) | HMG box A DNA-binding domain, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:Q567G0
|
198 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hmgb3b-201
(1)
|
Ensembl | 1,410 nt | ||
| mRNA |
hmgb3b-202
(1)
|
Ensembl | 794 nt | ||
| mRNA |
hmgb3b-203
(1)
|
Ensembl | 604 nt |
Interactions and Pathways
No data available
Plasmids
No data available