ZFIN is now using GRCz12tu for Genomic Data
Gene
exosc2
- ID
- ZDB-GENE-050417-27
- Name
- exosome component 2
- Symbol
- exosc2 Nomenclature History
- Previous Names
-
- fa97b01
- wu:fa97b01
- zgc:110117
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within neural retina development; ribonucleotide metabolic process; and spinal cord development. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in immature eye; midbrain hindbrain boundary; and optic tectum. Human ortholog(s) of this gene implicated in short stature, hearing loss, retinitis pigmentosa, and distinctive facies. Orthologous to human EXOSC2 (exosome component 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6903240 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Yatsuka et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| short stature, hearing loss, retinitis pigmentosa, and distinctive facies | Alliance | Short stature, hearing loss, retinitis pigmentosa, and distinctive facies | 617763 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004088 | K Homology domain, type 1 |
| Domain | IPR025721 | Exosome complex component, N-terminal domain |
| Domain | IPR048565 | RRP4, S1 domain |
| Family | IPR026699 | Exosome complex RNA-binding protein 1/RRP40/RRP4 |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR036612 | K Homology domain, type 1 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Exosome complex component, N-terminal domain | Exosome complex RNA-binding protein 1/RRP40/RRP4 | K Homology domain, type 1 | K Homology domain, type 1 superfamily | Nucleic acid-binding, OB-fold | RRP4, S1 domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F8W3K6 | InterPro | 295 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
exosc2-201
(1)
|
Ensembl | 1,032 nt | ||
| ncRNA |
exosc2-002
(1)
|
Ensembl | 782 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers