ZFIN is now using GRCz12tu for Genomic Data
Gene
prkar1ab
- ID
- ZDB-GENE-050417-238
- Name
- protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b
- Symbol
- prkar1ab Nomenclature History
- Previous Names
-
- zgc:112145
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease 1. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112145 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrodysostosis | Alliance | Acrodysostosis 1, with or without hormone resistance | 101800 |
| Carney complex | Alliance | Carney complex, type 1 | 160980 |
| primary pigmented nodular adrenocortical disease 1 | Alliance | Pigmented nodular adrenocortical disease, primary, 1 | 610489 |
| Adrenocortical tumor, somatic | |||
| Myxoma, intracardiac | 255960 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR003117 | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain |
| Family | IPR012198 | cAMP-dependent protein kinase regulatory subunit |
| Family | IPR050503 | cAMP-dependent protein kinase regulatory subunit-like |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | cAMP-dependent protein kinase regulatory subunit | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | cAMP-dependent protein kinase regulatory subunit-like | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q567D1 | InterPro | 379 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkar1ab-201
(1)
|
Ensembl | 1,829 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers