Gene
agr2
- ID
- ZDB-GENE-050417-214
- Name
- anterior gradient 2
- Symbol
- agr2 Nomenclature History
- Previous Names
-
- sb:eu228
- wu:fj29g05
- zgc:112187
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable identical protein binding activity. Acts upstream of or within intestinal epithelial cell differentiation. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including digestive system; hatching gland; integument; olfactory system; and vestibuloauditory system. Orthologous to human AGR2 (anterior gradient 2, protein disulphide isomerase family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 50 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu228 (13 images)
- IMAGE:7163877 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Chen et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013456Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-agr2 | N/A | Chen et al., 2012 |
| MO2-agr2 | N/A | Chen et al., 2012 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Respiratory infections, recurrent, and failure to thrive with or without diarrhea | 620233 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Anterior Gradient and Thioredoxin Domain | Thioredoxin-like superfamily |
|---|---|---|---|---|
| UniProtKB:Q5RZ65 | InterPro | 171 |
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-2.0agr2:EGFP) |
|
| 1 | (3) | |
| Tg(-2.4agr2:EGFP) |
|
| 1 | (3) | |
| Tg(-2.6agr2:EGFP) |
|
| 1 | (3) | |
| Tg2(agr2:EGFP) |
|
| 1 | Lai et al., 2016 | |
| Tg2(Hsa.AGR2-agr2:EGFP) |
|
| 1 | Lai et al., 2016 | |
| Tg(-3.3agr2:EGFP) |
|
| 1 | (3) | |
| Tg3(agr2:EGFP) |
|
| 1 | Lai et al., 2016 | |
| Tg3(Hsa.AGR2-agr2:EGFP) |
|
| 1 | Lai et al., 2016 | |
| Tg(-4.2agr2:EGFP) |
|
| 1 | Lai et al., 2016 | |
| Tg(-4.5agr2:EGFP) |
|
| 1 | Lai et al., 2016 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-201M19 | ZFIN Curated Data | |
| Encodes | EST | eu228 | Thisse et al., 2005 | |
| Encodes | EST | fj29g05 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7163877 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:112187 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:173722 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001012481 (1) | 1137 nt | ||
| Genomic | GenBank:BX547939 (2) | 215708 nt | ||
| Polypeptide | UniProtKB:Q5RZ65 (1) | 171 aa |
- Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Morales, R.A., Rabahi, S., Diaz, O.E., Salloum, Y., Kern, B.C., Westling, M., Luo, X., Parigi, S.M., Monasterio, G., Das, S., Hernández, P.P., Villablanca, E.J. (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal immunology. 15(5):940-951
- Reuter, A.S., Stern, D., Bernard, A., Goossens, C., Lavergne, A., Flasse, L., Von Berg, V., Manfroid, I., Peers, B., Voz, M.L. (2022) Identification of an evolutionarily conserved domain in Neurod1 favouring enteroendocrine versus goblet cell fate. PLoS Genetics. 18:e1010109
- Blitz, E., Matsuda, H., Guenther, S., Morikawa, T., Kubota, Y., Zada, D., Lerer-Goldshtein, T., Stainier, D.Y.R., Appelbaum, L. (2021) Thyroid hormones regulate goblet cell differentiation and Fgf19-Fgfr4 signaling. Endocrinology. 162(5):
- Lu, Y.F., Liu, D.W., Li, I.C., Lin, J., Wang, C.M., Chu, K.C., Kuo, H.H., Lin, C.Y., Yih, L.H., Jiang, Y.J., Hwang, S.L. (2021) Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos. PLoS Genetics. 17:e1009969
- Metikala, S., Casie Chetty, S., Sumanas, S. (2021) Single-cell transcriptome analysis of the zebrafish embryonic trunk. PLoS One. 16:e0254024
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Gu, W., Liu, S., Chen, L., Liu, Y., Gu, C., Ren, H.Q., Wu, B. (2020) Single-cell RNA sequencing reveals size-dependent effects of polystyrene microplastics on immune and secretory cell populations from zebrafish intestines. Environmental science & technology. 54(6):3417-3427
- Hou, Y., Lee, H.J., Chen, Y., Ge, J., Osman, F.O.I., McAdow, A.R., Mokalled, M.H., Johnson, S.L., Zhao, G., Wang, T. (2020) Cellular diversity of the regenerating caudal fin. Science advances. 6:eaba2084
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