Gene

azin1a

ID

ZDB-GENE-050417-20

Name

antizyme inhibitor 1a

Symbol

azin1a Nomenclature History

Previous Names

wu:fc93f10
zgc:110131

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable ornithine decarboxylase activator activity and ornithine decarboxylase activity. Predicted to be involved in negative regulation of protein catabolic process; positive regulation of polyamine transmembrane transport; and putrescine biosynthetic process from ornithine. Predicted to act upstream of or within polyamine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in hindbrain neural plate; immature eye; nervous system; and notochord. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110131 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With azin1a Human Ortholog

No data available

Associated With azin1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR022643	Orn/DAP/Arg decarboxylase 2, C-terminal
Domain	IPR022644	Orn/DAP/Arg decarboxylase 2, N-terminal
Family	IPR000183	Ornithine/DAP/Arg decarboxylase
Family	IPR002433	Ornithine decarboxylase
Homologous_superfamily	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal
Homologous_superfamily	IPR029066	PLP-binding barrel

Domain Details Per Protein

Protein	Length	Alanine racemase/group IV decarboxylase, C-terminal	Orn/DAP/Arg decarboxylase 2, C-terminal	Orn/DAP/Arg decarboxylase 2, N-terminal	Ornithine/DAP/Arg decarboxylase	Ornithine decarboxylase	PLP-binding barrel
UniProtKB:A0A8M1N598 InterPro	454

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	azin1a-201 (1) Ensembl	Ensembl	2,526 nt	Select Tool ZFIN BLAST
mRNA	azin1a-203 (1) Ensembl	Ensembl	581 nt	Select Tool ZFIN BLAST
mRNA	azin1a-204 (1) Ensembl	Ensembl	2,297 nt	Select Tool ZFIN BLAST
mRNA	azin1a-205 (1) Ensembl	Ensembl	599 nt	Select Tool ZFIN BLAST
ncRNA	azin1a-003 (1) Ensembl	Ensembl	647 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations