Gene
dync1li2
- ID
- ZDB-GENE-050417-156
- Name
- dynein, cytoplasmic 1, light intermediate chain 2
- Symbol
- dync1li2 Nomenclature History
- Previous Names
-
- fc08b04
- wu:fc08b04
- zgc:112480
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable dynein heavy chain binding activity. Acts upstream of or within regulation of metaphase plate congression; regulation of mitotic cell cycle, embryonic; and regulation of mitotic spindle organization. Predicted to be located in cytoplasm and microtubule. Predicted to be part of cytoplasmic dynein complex. Predicted to colocalize with centrosome. Orthologous to human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6893383 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Mahale et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016140Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026092Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa15946 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34154 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-dync1li2 | N/A | (2) |
| MO2-dync1li2 | N/A | Mahale et al., 2016 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynein 1 light intermediate chain | Dynein family light intermediate chain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BDX2 | InterPro | 469 | |||
| UniProtKB:F1RB89 | InterPro | 500 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dync1li2-201
(1)
|
Ensembl | 4,489 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-56M19 | ZFIN Curated Data | |
| Encodes | EST | fc08b04 | ||
| Encodes | EST | IMAGE:6893383 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:112480 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174291 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192709 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017669 (1) | 1561 nt | ||
| Genomic | GenBank:BX004979 (1) | 186642 nt | ||
| Polypeptide | UniProtKB:F1RB89 (1) | 500 aa |
- Zhao, X., Garcia, J.Q., Tong, K., Chen, X., Yang, B., Li, Q., Dai, Z., Shi, X., Seiple, I.B., Huang, B., Guo, S. (2021) Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Science advances. 7(24)
- Drerup, C.M., Herbert, A.L., Monk, K.R., Nechiporuk, A.V. (2017) Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. eLIFE. 6
- Mahale, S., Kumar, M., Sharma, A., Babu, A., Ranjan, S., Sachidanandan, C., Mylavarapu, S.V. (2016) The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Scientific Reports. 6:22
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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