Gene
prkn
- ID
- ZDB-GENE-050417-109
- Name
- parkin RBR E3 ubiquitin protein ligase
- Symbol
- prkn Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within several processes, including mitochondrial electron transport, NADH to ubiquinone; protein autoubiquitination; and response to temperature stimulus. Located in cytoplasm. Is expressed in several structures, including digestive system; gill; heart; nervous system; and somite. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 2; lung cancer; and ovarian cancer. Orthologous to human PRKN (parkin RBR E3 ubiquitin protein ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112390 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Flinn et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la012353Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa45478 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-prkn | Wrighton et al., 2021 | |
| MO1-prkn | N/A | Flinn et al., 2009 |
| MO2-prkn | N/A | Flinn et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung cancer | Alliance | Adenocarcinoma of lung, somatic | 211980 |
| ovarian cancer | Alliance | Ovarian cancer, somatic | 167000 |
| Parkinson's disease 2 | Alliance | Parkinson disease, juvenile, type 2 | 600116 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Parkinson's disease | WT + MO1-prkn + MO2-prkn | standard conditions | Flinn et al., 2009 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000626 | Ubiquitin-like domain |
| Domain | IPR002867 | IBR domain |
| Domain | IPR041170 | RING/Ubox-like zinc-binding domain |
| Domain | IPR041565 | Parkin, RING/Ubox like zinc-binding domain |
| Domain | IPR044066 | TRIAD supradomain |
| Domain | IPR047534 | E3 ubiquitin-protein ligase parkin, BRcat domain |
| Domain | IPR047535 | E3 ubiquitin-protein ligase parkin, RING finger, HC subclass |
| Domain | IPR047536 | E3 ubiquitin-protein ligase parkin, Rcat domain |
| Domain | IPR054694 | E3 ubiquitin-protein ligase parkin-like, IBR domain |
| Family | IPR003977 | E3 ubiquitin-protein ligase parkin |
| Family | IPR031127 | E3 ubiquitin ligase RBR family |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | E3 ubiquitin ligase RBR family | E3 ubiquitin-protein ligase parkin | E3 ubiquitin-protein ligase parkin, BRcat domain | E3 ubiquitin-protein ligase parkin-like, IBR domain | E3 ubiquitin-protein ligase parkin, Rcat domain | E3 ubiquitin-protein ligase parkin, RING finger, HC subclass | IBR domain | Parkin, RING/Ubox like zinc-binding domain | RING/Ubox-like zinc-binding domain | TRIAD supradomain | Ubiquitin-like domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q561U2 | InterPro | 458 | ||||||||||||
| UniProtKB:A0AB13ABF7 | InterPro | 458 |
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-15D5 | ZFIN Curated Data | |
| Contained in | BAC | CH73-193I2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-123F21 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:112390 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191712 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423707 (1) | 2082 nt | ||
| Genomic | GenBank:CR318584 (1) | 138029 nt | ||
| Polypeptide | UniProtKB:A0AB13ABF7 (1) | 458 aa |
- Bagwell, E., Shin, M., Henkel, N., Migliaccio, D., Peng, C., Larsen, J. (2024) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated adult zebrafish as a model for Parkinson's Disease. Neuroscience letters. 842:137991
- Grepper, D., Tabasso, C., Zanou, N., Aguettaz, A.K.F., Castro-Sepulveda, M., Ziegler, D.V., Lagarrigue, S., Arribat, Y., Martinotti, A., Ebrahimi, A., Daraspe, J., Fajas, L., Amati, F. (2024) BCL2L13 at endoplasmic reticulum-mitochondria contact sites regulates calcium homeostasis to maintain skeletal muscle function. iScience. 27:110510110510
- Hedayatikatouli, F., Kalyn, M., Elsaid, D., Mbesha, H.A., Ekker, M. (2024) Neuroprotective Effects of Ascorbic Acid, Vanillic Acid, and Ferulic Acid in Dopaminergic Neurons of Zebrafish. Biomedicines. 12(11):
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Cansiz, D., Unal, I., Beler, M., Ustundag, U.V., Ak, E., Emekli-Alturfan, E., Alturfan, A.A. (2023) The Effect of Acetic Acid-Induced Pain in Parkinson's Disease Model in Zebrafish. Neurotoxicology. 99:14-23
- Khalili, A., Safarian, N., van Wijngaarden, E., Zoidl, G.S., Zoidl, G.R., Rezai, P. (2023) Loss of Panx1 function in zebrafish alters motor behavior in a lab-on-chip model of Parkinson's disease. Journal of neuroscience research. 101(12):1814-1825
- Razali, K., Mohd Nasir, M.H., Kumar, J., Mohamed, W.M.Y. (2023) Mitophagy: A Bridge Linking HMGB1 and Parkinson's Disease Using Adult Zebrafish as a Model Organism. Brain sciences. 13(7):
- Dong, Y., Yu, M., Wu, Y., Xia, T., Wang, L., Song, K., Zhang, C., Lu, K., Rahimnejad, S. (2022) Hydroxytyrosol Promotes the Mitochondrial Function through Activating Mitophagy. Antioxidants (Basel, Switzerland). 11(5)
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Ren, Q., Jiang, X., Paudel, Y.N., Gao, X., Gao, D., Zhang, P., Sheng, W., Shang, X., Liu, K., Zhang, X., Jin, M. (2022) Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish. Journal of ethnopharmacology. 292:115234
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