Gene
fancg
- ID
- ZDB-GENE-050417-103
- Name
- FA complementation group G
- Symbol
- fancg Nomenclature History
- Previous Names
-
- zgc:109717
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be involved in DNA damage response. Predicted to act upstream of or within interstrand cross-link repair. Predicted to be part of Fanconi anaemia nuclear complex. Is expressed in several structures, including gonad; heart; nervous system; oral epithelium; and rostral blood island. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group G; and pancreatic cancer. Orthologous to human FANCG (FA complementation group G).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109717 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ramanagoudr-Bhojappa et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fanconi anemia complementation group G | Alliance | Fanconi anemia, complementation group G | 614082 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fanconi anemia group G protein | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat |
|---|---|---|---|---|---|
| UniProtKB:Q70YH6 | InterPro | 617 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-113N10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109717 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192943 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_205639 (1) | 2253 nt | ||
| Genomic | GenBank:CR558303 (1) | 155098 nt | ||
| Polypeptide | UniProtKB:Q70YH6 (1) | 617 aa |
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Ramanagoudr-Bhojappa, R., Carrington, B., Ramaswami, M., Bishop, K., Robbins, G.M., Jones, M., Harper, U., Frederickson, S.C., Kimble, D.C., Sood, R., Chandrasekharappa, S.C. (2018) Multiplexed CRISPR/Cas9-mediated knockout of 19 Fanconi anemia pathway genes in zebrafish revealed their roles in growth, sexual development and fertility. PLoS Genetics. 14:e1007821
- Titus, T.A., Yan, Y.L., Wilson, C., Starks, A.M., Frohnmayer, J.D., Canestro, C., Rodriguez-Mari, A., He, X., and Postlethwait, J.H. (2009) The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics. Mutation research. 668(1-2):117-132
- Titus, T.A., Selvig, D.R., Qin, B., Wilson, C., Starks, A.M., Roe, B.A., and Postlethwait, J.H. (2006) The Fanconi anemia gene network is conserved from zebrafish to human. Gene. 371(2):211-223
- Blom, E., van de Vrugt, H.J., Vries, Y., de Winter, J.P., Arwert, F., and Joenje, H. (2004) Multiple TPR motifs characterize the Fanconi anemia FANCG protein. DNA repair. 3(1):77-84
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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