Gene

pik3c3

ID

ZDB-GENE-050410-13

Name

phosphatidylinositol 3-kinase, catalytic subunit type 3

Symbol

pik3c3 Nomenclature History

Previous Names

im:7147158
wu:fc13g06
wu:fz51e12
zgc:112016
zgc:113009

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-kinase activity. Predicted to be involved in several processes, including autophagosome assembly; phosphatidylinositol metabolic process; and phosphatidylinositol-mediated signaling. Predicted to localize to several cellular components, including peroxisome; phagophore assembly site; and phosphatidylinositol 3-kinase complex, class III. Used to study inflammatory bowel disease. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147158 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from Zhao et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pik3c3 Human Ortholog

No data available

Associated With pik3c3 Via Experimental Models

Human Disease	Fish	Conditions	Citations
inflammatory bowel disease	pik3c3^{zf2161/zf2161}	standard conditions	Zhao et al., 2018
inflammatory bowel disease	pik3c3^{zf2160/zf2160}	standard conditions	Zhao et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
Domain	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
Domain	IPR002420	C2 phosphatidylinositol 3-kinase-type domain
Family	IPR008290	Phosphatidylinositol 3-kinase, Vps34 type
Family	IPR015433	Phosphatidylinositol kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	C2 domain superfamily	C2 phosphatidylinositol 3-kinase-type domain	Phosphatidylinositol 3-/4-kinase, catalytic domain	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Phosphatidylinositol 3/4-kinase, conserved site	Phosphatidylinositol 3-kinase, Vps34 type	Phosphatidylinositol kinase	Phosphoinositide 3-kinase, accessory (PIK) domain	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Protein kinase-like domain superfamily
UniProtKB:A0A8M9QGZ6 InterPro	887
UniProtKB:F1Q9F3 InterPro	878

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
aberrant processed transcript	pik3c3-202 (1) Ensembl	Ensembl		2,895 nt	Select Tool ZFIN BLAST
mRNA	pik3c3-201 (1) Ensembl	Ensembl		3,188 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations