Gene
man2b1
- ID
- ZDB-GENE-050327-52
- Name
- mannosidase, alpha, class 2B, member 1
- Symbol
- man2b1 Nomenclature History
- Previous Names
-
- zgc:110815
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable alpha-mannosidase activity. Predicted to act upstream of or within mannose metabolic process. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alpha-mannosidosis | Alliance | Mannosidosis, alpha-, types I and II | 248500 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000602 | Glycoside hydrolase family 38, N-terminal domain |
| Domain | IPR011682 | Glycosyl hydrolase family 38, C-terminal |
| Domain | IPR015341 | Glycoside hydrolase family 38, central domain |
| Domain | IPR041147 | Glycosyl hydrolases family 38, C-terminal beta sandwich domain |
| Domain | IPR048534 | Lysosomal alpha-mannosidase-like, central domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Galactose mutarotase-like domain superfamily | Glycoside hydrolase 38, N-terminal domain superfamily | Glycoside hydrolase/deacetylase, beta/alpha-barrel | Glycoside hydrolase families 57/38, central domain superfamily | Glycoside hydrolase family 38, central domain | Glycoside hydrolase family 38, central domain superfamily | Glycoside hydrolase family 38, N-terminal domain | Glycosyl hydrolase, all-beta | Glycosyl Hydrolase Family 38 | Glycosyl hydrolase family 38, C-terminal | Glycosyl hydrolases family 38, C-terminal beta sandwich domain | Lysosomal alpha-mannosidase-like, central domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q58EM3 | InterPro | 982 | ||||||||||||
| UniProtKB:A0A8M2BH83 | InterPro | 984 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
man2b1-201
(1)
|
Ensembl | 3,346 nt | ||
| mRNA |
man2b1-202
(1)
|
Ensembl | 898 nt |
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Interactions and Pathways
No data available
Plasmids
No data available