ZFIN ID: ZDB-GENE-050320-92
Gene Name: cadherin 6
Gene Symbol: cdh6    Nomenclature History

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Previous Name: zgc:103673

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have cadherin binding activity and calcium ion binding activity. Involved in pronephros development and retina morphogenesis in camera-type eye. Predicted to localize to adherens junction and catenin complex. Is expressed in several structures, including nervous system; neural crest cell; pronephros; trigeminal placode; and trunk mesenchyme. Orthologous to several human genes including CDH6 (cadherin 6).
Genome Resources: Alliance (1),  Gene:541393 (1),  Ensembl(GRCz11):ENSDARG00000014522 (2)
GENE EXPRESSION
All Expression Data: 26 figures from 8 publications
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19781 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cdh6 N/A 4
    MO2-cdh6 N/A 1
    MO3-cdh6 N/A 2
    MO4-cdh6 N/A 1
    DISEASE ASSOCIATED WITH cdh6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdh6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephros development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdh6-202 (1)    Ensembl 4217
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cdh6 polyclonal Rabbit IHC, WB Covance
    1
    Ab2-cdh6 polyclonal Rabbit 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdh6 No data available
    MARKER RELATIONSHIPS
    cdh6 Contained in: [BAC] DKEY-151M6 (1) (order this)
    cdh6 Encodes: [cDNA] MGC:103673 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013520 (1) 4275 nt
    Genomic GenBank:CR925777 (1) 210659 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5BKW2 (1) 794 aa
    Sequence Information (all 14)
    ORTHOLOGY for cdh6 ( Chr: 2 )
    CITATIONS (31)