Gene
mybpc2b
- ID
- ZDB-GENE-050320-80
- Name
- myosin binding protein Cb
- Symbol
- mybpc2b Nomenclature History
- Previous Names
-
- im:7137115
- im:7150089
- zgc:110761
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Acts upstream of or within muscle tissue development. Predicted to be active in M band. Is expressed in several structures, including adaxial cell; musculature system; otic placode; otic vesicle; and trunk. Used to study myopathy. Orthologous to human MYBPC2 (myosin binding protein C2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150089 (13 images)
- IMAGE:7162921 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Li et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa10810 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19351 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24551 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37954 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mybpc2b | N/A | Li et al., 2016 |
| MO2-mybpc2b | N/A | Li et al., 2016 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myopathy | TU + MO1-mybpc2b | standard conditions | Li et al., 2016 |
| myopathy | TU + MO2-mybpc2b | standard conditions | Li et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR040849 | MyBP-C, tri-helix bundle domain |
| Family | IPR050964 | Striated Muscle Structural and Regulatory Protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin domain subtype | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype 2 | MyBP-C, tri-helix bundle domain | Striated Muscle Structural and Regulatory Protein |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6YW81 | InterPro | 1105 | ||||||||||
| UniProtKB:A0A8M9PLR4 | InterPro | 1110 | ||||||||||
| UniProtKB:A0A8M1N4T5 | InterPro | 1111 | ||||||||||
| UniProtKB:Q5BJ14 | InterPro | 1111 | ||||||||||
| UniProtKB:A0A8M9P5V8 | InterPro | 1103 | ||||||||||
| UniProtKB:A0A8M9PXG3 | InterPro | 1104 | ||||||||||
| UniProtKB:A0A8M9PU17 | InterPro | 1104 | ||||||||||
| UniProtKB:A0AB32TI46 | InterPro | 1103 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mybpc2b-201
(1)
|
Ensembl | 3,336 nt | ||
| mRNA |
mybpc2b-202
(1)
|
Ensembl | 3,789 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-78F13 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-334G13 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7137115 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7150089 | Thisse et al., 2004 | |
| Encodes | EST | IMAGE:7162921 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110761 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013511 (1) | 3926 nt | ||
| Genomic | GenBank:CU672238 (2) | 37950 nt | ||
| Polypeptide | UniProtKB:A0A8M1N4T5 (1) | 1111 aa |
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Da'as, S.I., Hasan, W., Salem, R., Younes, N., Abdelrahman, D., Mohamed, I.A., Aldaalis, A., Temanni, R., Mathew, L.S., Lorenz, S., Yacoub, M., Nomikos, M., Nasrallah, G.K., Fakhro, K.A. (2022) Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model. International Journal of Molecular Sciences. 23(16)
- Jin, X., Liu, W., Miao, J., Tai, Z., Li, L., Guan, P., Liu, J.X. (2021) Copper ions impair zebrafish skeletal myofibrillogenesis via epigenetic regulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 35:e21686
- Li, M., Andersson-Lendahl, M., Sejersen, T., Arner, A. (2016) Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy. The Journal of general physiology. 147:309-22
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Nolte, H., Konzer, A., Ruhs, A., Jungblut, B., Braun, T., Krüger, M. (2014) Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Journal of Proteome Research. 13:2162-74
- Chen, K., Cole, R.B., and Rees, B.B. (2013) Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. Journal of proteomics. 78:477-485
- Hawkins, T.A., Haramis, A.P., Etard, C., Prodromou, C., Vaughan, C.K., Ashworth, R., Ray, S., Behra, M., Holder, N., Talbot, W.S., Pearl, L.H., Strähle, U., and Wilson, S.W. (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development (Cambridge, England). 135(6):1147-1156
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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