Gene

mybpc2b

ID

ZDB-GENE-050320-80

Name

myosin binding protein Cb

Symbol

mybpc2b Nomenclature History

Previous Names

im:7137115
im:7150089
zgc:110761

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Involved in muscle tissue development. Used to study myopathy. Is expressed in several structures, including adaxial cell; musculature system; otic placode; otic vesicle; and trunk. Orthologous to human MYBPC2 (myosin binding protein C2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7150089 (13 images)
IMAGE:7162921 (18 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Li et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mybpc2b Human Ortholog

No data available

Associated With mybpc2b Via Experimental Models

Human Disease	Fish	Conditions	Citations
myopathy	TU + MO1-mybpc2b	standard conditions	Li et al., 2016
myopathy	TU + MO2-mybpc2b	standard conditions	Li et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR040849	MyBP-C, tri-helix bundle domain
Family	IPR050964	Striated Muscle Structural and Regulatory Protein
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	MyBP-C, tri-helix bundle domain	Striated Muscle Structural and Regulatory Protein
UniProtKB:A0A8M6YW81 InterPro	1105
UniProtKB:A0A8M9PLR4 InterPro	1110
UniProtKB:A0A8M1N4T5 InterPro	1111
UniProtKB:Q5BJ14 InterPro	1111
UniProtKB:A0A8M9P5V8 InterPro	1103
UniProtKB:A0A8M9PXG3 InterPro	1104
UniProtKB:A0A8M9PU17 InterPro	1104