Gene
aoc2
- ID
- ZDB-GENE-050320-133
- Name
- amine oxidase copper containing 2
- Symbol
- aoc2 Nomenclature History
- Previous Names
-
- fa94a08
- fe14c05
- wu:fa94a08
- wu:fe14c05
- zgc:113006
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable copper ion binding activity and primary methylamine oxidase activity. Predicted to be involved in amine metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AOC2 (amine oxidase copper containing 2) and AOC3 (amine oxidase copper containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR049947 | Copper amine oxidase, copper-binding site |
Domain | IPR015798 | Copper amine oxidase, catalytic domain |
Domain | IPR015800 | Copper amine oxidase, N2-terminal |
Domain | IPR015802 | Copper amine oxidase, N3-terminal |
Family | IPR000269 | Copper amine oxidase |
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Domain Details Per Protein
Protein | Additional Resources | Length | Copper amine oxidase | Copper amine oxidase, catalytic domain | Copper amine oxidase, catalytic domain superfamily | Copper amine oxidase, copper-binding site | Copper amine oxidase, N2-terminal | Copper amine oxidase, N3-terminal | Copper amine oxidase, N-terminal |
---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M1N4I9 | InterPro | 754 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-129K16 | ||
Contained in | BAC | DKEY-18H4 | ZFIN Curated Data | |
Encodes | EST | fa94a08 | ||
Encodes | EST | fe14c05 | ||
Encodes | cDNA | MGC:113006 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191495 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001013555 (1) | 2753 nt | ||
Genomic | GenBank:BX005142 (1) | 170200 nt | ||
Polypeptide | UniProtKB:A0A8M1N4I9 (1) | 754 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | AOC2 | 17 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) | |
Human | AOC3 | 17 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) | |
Mouse | Aoc2 | 11 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) | |
Mouse | Aoc3 | 11 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Liu, L., Song, D.W., Liu, G.L., Shan, L.P., Qiu, T.X., Chen, J. (2020) Hydroxycoumarin efficiently inhibits spring viraemia of carp virus infection in vitro and in vivo. Zoological research. 41(4):395-409
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Wang, Y., Zhang, H., Lu, Y., Wang, F., Liu, L., Liu, J., Liu, X. (2017) Comparative transcriptome analysis of zebrafish (Danio rerio) brain and spleen infected with spring viremia of carp virus (SVCV). Fish & shellfish immunology. 69:35-45
- Nakajima, H., Nakajima-Takagi, Y., Tsujita, T., Akiyama, S., Wakasa, T., Mukaigasa, K., Kaneko, H., Tamaru, Y., Yamamoto, M., and Kobayashi, M. (2011) Tissue-restricted expression of nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. PLoS One. 6(10):e26884
- Sundström, G., Larsson, T.A., Larhammar, D. (2008) Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. BMC Evolutionary Biology. 8(1):254
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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