Gene
dnmt3ba
- ID
- ZDB-GENE-050314-4
- Name
- DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
- Symbol
- dnmt3ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have DNA-methyltransferase activity. Involved in DNA methylation. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and rheumatoid arthritis. Is expressed in several structures, including alar plate midbrain region; eye; immature eye; midbrain; and pleuroperitoneal region. Orthologous to several human genes including DNMT3L (DNA methyltransferase 3 like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb91 (2 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| facioscapulohumeral muscular dystrophy 4 | Alliance | Facioscapulohumeral muscular dystrophy 4, digenic | 619478 |
| immunodeficiency-centromeric instability-facial anomalies syndrome 1 | Alliance | Immunodeficiency-centromeric instability-facial anomalies syndrome 1 | 242860 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018117 | DNA methylase, C-5 cytosine-specific, active site |
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000313 | PWWP domain |
| Domain | IPR001715 | Calponin homology domain |
| Domain | IPR025766 | ADD domain |
| Domain | IPR040552 | DNMT3, cysteine rich ADD domain, GATA1-like zinc finger |
| Domain | IPR049554 | DNMT3, ADD domain, PHD zinc finger |
| Family | IPR001525 | C-5 cytosine methyltransferase |
| Homologous_superfamily | IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
| Homologous_superfamily | IPR036872 | CH domain superfamily |
Domain Details Per Protein
| Protein | Length | ADD domain | C-5 cytosine methyltransferase | Calponin homology domain | CH domain superfamily | DNA methylase, C-5 cytosine-specific, active site | DNMT3, ADD domain, PHD zinc finger | DNMT3, cysteine rich ADD domain, GATA1-like zinc finger | EF-Hand 1, calcium-binding site | PWWP domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BEF6
|
1500 | ||||||||||
|
UniProtKB:B0S581
|
1433 | ||||||||||
|
UniProtKB:A0A2R9YJL5
|
1456 | ||||||||||
|
UniProtKB:A0A8M2BEG2
|
1477 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnmt3ba-201
(1)
|
Ensembl | 7,462 nt | ||
| mRNA |
dnmt3ba-202
(1)
|
Ensembl | 7,594 nt | ||
| mRNA |
dnmt3ba-203
(1)
|
Ensembl | 6,264 nt |
Interactions and Pathways
No data available
Plasmids
No data available