Gene

dnmt3ba

ID
ZDB-GENE-050314-4
Name
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
Symbol
dnmt3ba Nomenclature History
Previous Names
  • dnmt3b2 (1)
  • dnmt3b
  • dnmt3bl
  • dnmt7
  • cb91 (1)
  • sb:cb91 (1)
  • wu:fb16h07 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have DNA-methyltransferase activity. Involved in DNA methylation. Is expressed in several structures, including alar plate midbrain region; eye; immature eye; midbrain; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and rheumatoid arthritis. Orthologous to several human genes including DNMT3L (DNA methyltransferase 3 like).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnmt3ba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency-centromeric instability-facial anomalies syndrome 1 Alliance Immunodeficiency-centromeric instability-facial anomalies syndrome 1 242860
Facioscapulohumeral muscular dystrophy 4, digenic 619478
Associated With dnmt3ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018117 DNA methylase, C-5 cytosine-specific, active site
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR000313 PWWP domain
Domain IPR001715 Calponin homology domain
Domain IPR025766 ADD domain
Domain IPR030488 DNA (cytosine-5)-methyltransferase 3B, ADD domain
Domain IPR040552 DNMT3, cysteine rich ADD domain
Family IPR001525 C-5 cytosine methyltransferase
Homologous_superfamily IPR036872 CH domain superfamily
Domain Details Per Protein
Protein Length ADD domain C-5 cytosine methyltransferase Calponin homology domain CH domain superfamily DNA (cytosine-5)-methyltransferase 3B, ADD domain DNA methylase, C-5 cytosine-specific, active site DNMT3, cysteine rich ADD domain EF-Hand 1, calcium-binding site PWWP domain
UniProtKB:B0S581 1433
UniProtKB:A0A2R9YJL5 1456
UniProtKB:B3DJN5 1456
UniProtKB:E7F6H4 1500
UniProtKB:Q588C3 1433
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations