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ZIRC
ZFIN ID: ZDB-GENE-050314-4
Gene Name: DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a
Gene Symbol: dnmt3ba    Nomenclature History

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Previous Names: dnmt3b2 (1), dnmt3b, dnmt3bl, dnmt7, cb91 (1), sb:cb91 (1), wu:fb16h07 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have DNA-methyltransferase activity. Involved in DNA methylation. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and rheumatoid arthritis. Is expressed in several structures, including alar plate midbrain region; eye; immature eye; midbrain; and pleuroperitoneal region. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).
Genome Resources: Alliance (1),  Gene:321084 (1),  Ensembl(GRCz11):ENSDARG00000052402 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14480 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31654 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41193 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45320 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dnmt3ba N/A 2
    MO2-dnmt3ba N/A 1
    DISEASE ASSOCIATED WITH dnmt3ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    immunodeficiency-centromeric instability-facial anomalies syndrome 1 Alliance Immunodeficiency-centromeric instability-facial anomalies syndrome 1 242860
    DISEASE ASSOCIATED WITH dnmt3ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA methylation (more)
    Molecular Function DNA-methyltransferase activity (more)
    GO Terms (all 6)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dnmt3ba-203 (1)    Ensembl 6264
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dnmt3ba No data available
    MARKER RELATIONSHIPS
    dnmt3ba Contained in: [BAC] DKEY-16N15 (1) (order this), DKEY-80N10 (1) (order this)
    dnmt3ba Encodes: [EST] cb91 (1) (order this), fb16h07
    [cDNA] MGC:195103 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001020476 (1) 6248 bp
    Genomic GenBank:BX005340 (1) 119181 bp
    Select Tool
    Polypeptide UniProtKB:E7F6H4 (1) 1500 aa
    Sequence Clusters UniGene:104826 (1)
    Sequence Information (all 30)
    ORTHOLOGY for dnmt3ba ( Chr: 8 )
    CITATIONS (45)