Gene

dnmt3bb.3

ID

ZDB-GENE-050314-2

Name

DNA (cytosine-5-)-methyltransferase beta, duplicate b.3

Symbol

dnmt3bb.3 Nomenclature History

Previous Names

dnmt3-2 (1)
dnmt3b4 (1)
dnmt5
wu:fc08a10
zgc:136325

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and DNA binding activity. Predicted to be involved in C-5 methylation of cytosine and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA methylation and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including brain; digestive system; head; musculature system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta) and DNMT3L (DNA methyltransferase 3 like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnmt3bb.3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
facioscapulohumeral muscular dystrophy 4	Alliance	Facioscapulohumeral muscular dystrophy 4, digenic	619478
immunodeficiency-centromeric instability-facial anomalies syndrome 1	Alliance	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	242860

Associated With dnmt3bb.3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000313	PWWP domain
Domain	IPR025766	ADD domain
Domain	IPR040552	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
Domain	IPR049554	DNMT3, ADD domain, PHD zinc finger
Family	IPR001525	C-5 cytosine methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily

Domain Details Per Protein

Protein	Length	ADD domain	C-5 cytosine methyltransferase	DNMT3, ADD domain, PHD zinc finger	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger	PWWP domain	S-adenosyl-L-methionine-dependent methyltransferase superfamily
UniProtKB:A3QJU7 InterPro	1296
UniProtKB:Q588C5 InterPro	1297

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dnmt3bb.3-201 (1) Ensembl	Ensembl	3,891 nt	Select Tool ZFIN BLAST
mRNA	dnmt3bb.3-202 (1) Ensembl	Ensembl	1,689 nt	Select Tool ZFIN BLAST
mRNA	dnmt3bb.3-205 (1) Ensembl	Ensembl	4,418 nt	Select Tool ZFIN BLAST
mRNA	dnmt3bb.3-206 (1) Ensembl	Ensembl	771 nt	Select Tool ZFIN BLAST
ncRNA	dnmt3bb.3-004 (1) Ensembl	Ensembl	883 nt	Select Tool ZFIN BLAST
ncRNA	dnmt3bb.3-005 (1) Ensembl	Ensembl	599 nt	Select Tool ZFIN BLAST
ncRNA	dnmt3bb.3-006 (1) Ensembl	Ensembl	782 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations