Gene
ntn4
- ID
- ZDB-GENE-050310-1
- Name
- netrin 4
- Symbol
- ntn4 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Involved in vasculature development. Acts upstream of or within blood vessel morphogenesis. Predicted to be located in extracellular region. Predicted to be part of laminin complex. Is expressed in blood vessel; brain; neural rod; tail bud; and trunk. Orthologous to human NTN4 (netrin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Lambert et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ntn4 | N/A | Lambert et al., 2012 |
| MO2-ntn4 | N/A | Lambert et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Laminin/Netrin Extracellular Matrix | Laminin, N-terminal | Laminin-type EGF domain | Netrin-4, NTR domain | Netrin domain | Netrin module, non-TIMP type | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q32SK8 | InterPro | 558 | |||||||
| UniProtKB:A0A0R4IFE9 | InterPro | 639 | |||||||
| UniProtKB:A0AB13A9Z0 | InterPro | 593 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ntn4 | monoclonal | IgG2a | Mouse |
|
R&D Systems
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-196E11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195226 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001430983 (1) | 2402 nt | ||
| Genomic | GenBank:CR855334 (1) | 183043 nt | ||
| Polypeptide | UniProtKB:A0A0R4IFE9 (1) | 639 aa |
- Yao, H., Shen, Y., Song, Z., Han, A., Chen, X., Zhang, Y., Hu, B. (2024) Rab11 promotes single Mauthner cell axon regeneration in vivo through axon guidance molecule Ntng2b. Experimental neurology. 374:114715
- Gao, X., Metzger, U., Panza, P., Mahalwar, P., Alsheimer, S., Geiger, H., Maischein, H.M., Levesque, M.P., Templin, M., Söllner, C. (2015) A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Cell Reports. 12(4):694-708
- Lambert, E., Coissieux, M.M., Laudet, V., and Mehlen, P. (2012) Netrin-4 acts as a pro-angiogenic factor during zebrafish development. The Journal of biological chemistry. 287(6):3987-3999
- Park, K.W., Urness, L.D., Senchuk, M.M., Colvin, C.J., Wythe, J.D., Chien, C.B., and Li, D.Y. (2005) Identification of new netrin family members in zebrafish: Developmental expression of netrin2 and netrin4. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(3):726-731
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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