Gene
zfhx3a
- ID
- ZDB-GENE-050309-237
- Name
- zinc finger homeobox 3a
- Symbol
- zfhx3a Nomenclature History
- Previous Names
-
- im:7145045
- im:7152896 (1)
- si:ch73-386h18.1
- wu:fb53g09
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of neuron differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in central nervous system and telencephalon. Human ortholog(s) of this gene implicated in familial atrial fibrillation; hepatocellular carcinoma; lung non-small cell carcinoma (multiple); prostate cancer; and spinocerebellar ataxia type 4. Orthologous to human ZFHX3 (zinc finger homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145045 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial atrial fibrillation | Alliance | {Atrial fibrillation 8, susceptibility to} | 613055 |
| prostate cancer | Alliance | Prostate cancer, somatic | 176807 |
| spinocerebellar ataxia type 4 | Alliance | Spinocerebellar ataxia 4 | 600223 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR003604 | Matrin/U1-C-like, C2H2-type zinc finger |
| Domain | IPR013087 | Zinc finger C2H2-type |
| Family | IPR051968 | Zinc finger homeobox transcription regulators |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR036236 | Zinc finger C2H2 superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Matrin/U1-C-like, C2H2-type zinc finger | Zinc finger C2H2 superfamily | Zinc finger C2H2-type | Zinc finger homeobox transcription regulators |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q7K3 | InterPro | 3356 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch73-386h18.1-201
(1)
|
Ensembl | 13,619 nt | ||
| mRNA |
si:ch73-386h18.1-202
(1)
|
Ensembl | 13,161 nt |
Interactions and Pathways
No data available
Plasmids
No data available