Gene
ly75
- ID
- ZDB-GENE-050309-166
- Name
- lymphocyte antigen 75
- Symbol
- ly75 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable signaling receptor activity. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in heart and macrophage. Orthologous to human LY75 (lymphocyte antigen 75).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150926 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Haas et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6194 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17385 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35033 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa38827 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41788 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000562 | Fibronectin type II domain |
| Domain | IPR000772 | Ricin B, lectin domain |
| Domain | IPR001304 | C-type lectin-like |
| Family | IPR050111 | C-type lectin and snaclec domain-containing protein |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR016186 | C-type lectin-like/link domain superfamily |
| Homologous_superfamily | IPR016187 | C-type lectin fold |
| Homologous_superfamily | IPR035992 | Ricin B-like lectins |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C-type lectin and snaclec domain-containing protein | C-type lectin fold | C-type lectin-like | C-type lectin-like/link domain superfamily | Fibronectin type II domain | Fibronectin type II domain superfamily | Kringle-like fold | Ricin B, lectin domain | Ricin B-like lectins |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QS24 | InterPro | 1726 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-78P20 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7150926 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009305864 (1) | 6387 nt | ||
| Genomic | GenBank:CR847973 (2) | 116327 nt | ||
| Polypeptide | UniProtKB:F1QS24 (1) | 1726 aa |
- Capon, S.J., Uribe, V., Dominado, N., Ehrlich, O., Smith, K.A. (2022) Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2. Development (Cambridge, England). 149(9):
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Zhu, Z., Liu, Y., Xu, W., Liu, T., Xie, Y., Sham, K.W.Y., Sha, O., Cheng, C.H.K. (2020) Functional Characterization and Expression Analyses Show Differential Roles of Maternal and Zygotic Dgcr8 in Early Embryonic Development. Frontiers in genetics. 11:299
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Lui, E.Y., Li, C., Li, Z.H., Gong, Z., Lam, S.H. (2016) Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. Journal of genetics and genomics = Yi chuan xue bao. 43(8):525-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Presslauer, C., Nagasawa, K., Dahle, D., Babiak, J., Fernandes, J.M., Babiak, I. (2014) Induced Autoimmunity against Gonadal Proteins Affects Gonadal Development in Juvenile Zebrafish. PLoS One. 9:e114209
- Haas, J., Frese, K.S., Park, Y.J., Keller, A., Vogel, B., Lindroth, A.M., Weichenhan, D., Franke, J., Fischer, S., Bauer, A., Marquart, S., Sedaghat-Hamedani, F., Kayvanpour, E., Kohler, D., Wolf, N.M., Hassel, S., Nietsch, R., Wieland, T., Ehlermann, P., Schultz, J.H., Dosch, A., Mereles, D., Hardt, S., Backs, J., Hoheisel, J.D., Plass, C., Katus, H.A., and Meder, B. (2013) Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Molecular Medicine. 5(3):413-429
- Kasai, K., Nishiyama, N., and Yamauchi, K. (2013) Characterization of Oncorhynchus mykiss 5-hydroxyisourate hydrolase/transthyretin superfamily: evolutionary and functional analyses. Gene. 531(2):326-336
- Nagasawa, K., Fernandes, J.M., Yoshizaki, G., Miwa, M., and Babiak, I. (2013) Identification and migration of primordial germ cells in Atlantic salmon, Salmo salar: Characterization of vasa, dead end, and lymphocyte antigen 75 genes. Molecular reproduction and development. 80(2):118-131
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