Gene
rbm8a
- ID
- ZDB-GENE-050306-51
- Name
- RNA binding motif protein 8A
- Symbol
- rbm8a Nomenclature History
- Previous Names
-
- fb34f03
- wu:fb34f03
- zgc:110525 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Contributes to mRNA binding activity. Acts upstream of or within regulation of gene expression. Part of exon-exon junction complex. Human ortholog(s) of this gene implicated in thrombocytopenia-absent radius syndrome. Orthologous to human RBM8A (RNA binding motif protein 8A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110525 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Gangras et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-rbm8a | Gangras et al., 2020 | |
| CRISPR2-rbm8a | LaCoursiere et al., 2024 | |
| CRISPR3-rbm8a | LaCoursiere et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombocytopenia-absent radius syndrome | Alliance | Thrombocytopenia-absent radius syndrome | 274000 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR033744 | RBM8, RNA recognition motif |
| Family | IPR008111 | RNA-binding motif protein 8 |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RBM8, RNA recognition motif | RNA-binding domain superfamily | RNA-binding motif protein 8 | RNA recognition motif domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q5D018
|
174 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-45N22 | ZFIN Curated Data | |
| Encodes | EST | fb34f03 | ||
| Encodes | EST | IMAGE:6897836 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:110525 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013345 (1) | 910 nt | ||
| Genomic | GenBank:CR933818 (1) | 243546 nt | ||
| Polypeptide | UniProtKB:Q5D018 (1) | 174 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Valcarce, D.G., Riesco, M.F., Cuesta-Martín, L., Esteve-Codina, A., Martínez-Vázquez, J.M., Robles, V. (2023) Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny. BMC Biology. 21:7070
- Gangras, P., Gallagher, T.L., Parthun, M.A., Yi, Z., Patton, R.D., Tietz, K.T., Deans, N.C., Bundschuh, R., Amacher, S.L., Singh, G. (2020) Zebrafish rbm8a and magoh mutants reveal EJC developmental functions and new 3'UTR intron-containing NMD targets. PLoS Genetics. 16:e1008830
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Quiniou, S.M., Wilson, M., and Boudinot, P. (2011) Processing of fish Ig heavy chain transcripts: Diverse splicing patterns and unusual nonsense mediated decay. Developmental and comparative immunology. 35(9):949-58
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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