Gene
scube2
- ID
- ZDB-GENE-050302-80
- Name
- signal peptide, CUB domain, EGF-like 2
- Symbol
- scube2 Nomenclature History
- Previous Names
-
- U shaped somites
- u-shaped somites (1)
- wu:fc27f08
- you
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Involved in several processes, including muscle cell fate specification; muscle fiber development; and negative regulation of BMP signaling pathway. Localizes to cell surface; extracellular region; and secretory granule. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural rod; midbrain neural rod; neural keel; and trunk. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
Domain | IPR000742 | EGF-like domain |
Domain | IPR000859 | CUB domain |
Domain | IPR001881 | EGF-like calcium-binding domain |
Domain | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
Domain | IPR024731 | EGF domain |
Domain | IPR026823 | Complement Clr-like EGF domain |
Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
Family | IPR052071 | Signal peptide, CUB and EGF-like domain-containing protein |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
Protein | Length | Complement Clr-like EGF domain | CUB domain | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | NOTCH1 EGF-like calcium-binding domain | Signal peptide, CUB and EGF-like domain-containing protein | Spermadhesin, CUB domain superfamily | Tyrosine-protein kinase ephrin type A/B receptor-like |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2BDX4
|
854 | ||||||||||||
UniProtKB:A0A0B5JWE1
|
1010 | ||||||||||||
UniProtKB:A0A8M9PNW8
|
853 | ||||||||||||
UniProtKB:A0A8M2BDV7
|
1009 | ||||||||||||
UniProtKB:Q5G872
|
1010 | ||||||||||||
UniProtKB:A0A8M9QBZ2
|
971 | ||||||||||||
UniProtKB:A0A8M2BDU1
|
1009 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
scube2-201
(1)
|
Ensembl | 3,969 nt |
Interactions and Pathways
No data available
Plasmids