ZFIN is now using GRCz12tu for Genomic Data
Gene
scube2
- ID
- ZDB-GENE-050302-80
- Name
- signal peptide, CUB domain, EGF-like 2
- Symbol
- scube2 Nomenclature History
- Previous Names
-
- U shaped somites
- u-shaped somites (1)
- wu:fc27f08
- you
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including muscle cell fate specification; negative regulation of BMP signaling pathway; and sprouting angiogenesis. Located in cell surface; extracellular region; and secretory granule. Is expressed in several structures, including central nervous system; midbrain hindbrain boundary neural rod; midbrain neural rod; neural keel; and trunk. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
| Domain | IPR024731 | EGF domain |
| Domain | IPR026823 | Complement Clr-like EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR052071 | Signal peptide, CUB and EGF-like domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement Clr-like EGF domain | CUB domain | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | NOTCH1 EGF-like calcium-binding domain | Signal peptide, CUB and EGF-like domain-containing protein | Spermadhesin, CUB domain superfamily | Tyrosine-protein kinase ephrin type A/B receptor-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BDX4 | InterPro | 854 | ||||||||||||
| UniProtKB:A0A0B5JWE1 | InterPro | 1010 | ||||||||||||
| UniProtKB:A0A8M9PNW8 | InterPro | 853 | ||||||||||||
| UniProtKB:A0A8M2BDV7 | InterPro | 1009 | ||||||||||||
| UniProtKB:Q5G872 | InterPro | 1010 | ||||||||||||
| UniProtKB:A0A8M9QBZ2 | InterPro | 971 | ||||||||||||
| UniProtKB:A0A8M2BDU1 | InterPro | 1009 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
scube2-201
(1)
|
Ensembl | 3,969 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers