Gene
apoa1b
- ID
- ZDB-GENE-050302-172
- Name
- apolipoprotein A-Ib
- Symbol
- apoa1b Nomenclature History
- Previous Names
-
- wu:fb66d03
- wu:fd19c08
- xx:sd49
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol transfer activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to act upstream of or within lipid transport and steroid metabolic process. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in blood; liver; otolith; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hypoalphalipoproteinemia 2 | Alliance | Hypoalphalipoproteinemia, primary, 2 | 618463 |
| Amyloidosis, hereditary systemic 3 | 620657 | ||
| Hypoalphalipoproteinemia, primary, 2, intermediate | 619836 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|---|
| UniProtKB:A0A0R4IKF0 | InterPro | 257 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apoa1b-201
(1)
|
Ensembl | 1,170 nt | ||
| mRNA |
apoa1b-202
(1)
|
Ensembl | 735 nt | ||
| mRNA |
apoa1b-203
(1)
|
Ensembl | 4,170 nt |
Interactions and Pathways
No data available
Plasmids