Gene
crygs1
- ID
- ZDB-GENE-050223-4
- Name
- crystallin, gamma S1
- Symbol
- crygs1 Nomenclature History
- Previous Names
-
- gammaSa-crystallin
- zgc:136658
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of eye lens. Predicted to be involved in lens development in camera-type eye and visual perception. Is expressed in eye and lens.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3154 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32385 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37447 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37448 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa43789 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Beta/gamma crystallin | Beta/Gamma-Crystallin | Gamma-crystallin-like |
|---|---|---|---|---|---|
| UniProtKB:E9QE97 | InterPro | 178 | |||
| UniProtKB:Q5XTP0 | InterPro | 174 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
crygs1-201
(1)
|
Ensembl | 703 nt | ||
| mRNA |
crygs1-202
(1)
|
Ensembl | 710 nt | ||
| mRNA |
crygs1-203
(1)
|
Ensembl | 1,085 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-78I5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136658 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423695 (1) | 725 nt | ||
| Genomic | GenBank:CU041376 (1) | 99510 nt | ||
| Polypeptide | UniProtKB:E9QE97 (1) | 178 aa |
No data available
- Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Eastlake, K., Heywood, W.E., Tracey-White, D., Aquino, E., Bliss, E., Vasta, G.R., Mills, K., Khaw, P.T., Moosajee, M., Limb, G.A. (2017) Comparison of proteomic profiles in the zebrafish retina during experimental degeneration and regeneration. Scientific Reports. 7:44601
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Hinaux, H., Blin, M., Fumey, J., Legendre, L., Heuzé, A., Casane, D., Rétaux, S. (2015) Lens defects in Astyanax mexicanus cavefish: evolution of crystallins and a role for alphaA-crystallin. Developmental Neurobiology. 75(5):505-21
- Wages, P., Horwitz, J., Ding, L., Corbin, R.W., and Posner, M. (2013) Changes in zebrafish (Danio rerio) lens crystallin content during development. Molecular Vision. 19:408-417
- Greiling, T.M., Houck, S.A., and Clark, J.I. (2009) The zebrafish lens proteome during development and aging. Molecular Vision. 15:2313-2325
- Posner, M., Hawke, M., Lacava, C., Prince, C.J., Bellanco, N.R., and Corbin, R.W. (2008) A proteome map of the zebrafish (Danio rerio) lens reveals similarities between zebrafish and mammalian crystallin expression. Molecular Vision. 14:806-814
- Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Molecular Vision. 11:1083-1100
- Wistow, G., Wyatt, K., David, L., Gao, C., Bateman, O., Bernstein, S., Tomarev, S., Segovia, L., Slingsby, C., and Vihtelic, T. (2005) gammaN-crystallin and the evolution of the betagamma-crystallin superfamily in vertebrates. The FEBS journal. 272(9):2276-2291
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