ZFIN ID: ZDB-GENE-050221-1
Gene Name: guanine nucleotide binding protein (G protein) alpha 12a
Gene Symbol: gna12a    Nomenclature History

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Previous Names: gna12, gna12l (1), Galpha 12 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including gastrulation; glial cell development; and negative regulation of cell-cell adhesion mediated by cadherin. Predicted to localize to brush border membrane and heterotrimeric G-protein complex. Is expressed in brain; gill; head; and olfactory epithelium. Orthologous to human GNA12 (G protein subunit alpha 12).
Genome Resources: Alliance (1),  Gene:503589 (1),  Ensembl(GRCz11):ENSDARG00000025826 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
nksagm18cGt Transgenic Insertion Unknown Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-gna12a N/A 6
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gna12a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH gna12a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cell migration involved in gastrulation (more)
Cellular Component brush border membrane (more)
Molecular Function G-protein beta/gamma-subunit complex binding (more)
GO Terms (all 23)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gna12a-201 (1)    Ensembl 4379
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gna12a No data available
MARKER RELATIONSHIPS
gna12a Contained in: [BAC] DKEY-250F19 (1) (order this)
gna12a Encodes: [EST] wz10433 (1)
[cDNA] MGC:158144 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001013277 (1) 4423 nt
Genomic GenBank:BX324110 (1) 103014 nt
Select Tool
Polypeptide UniProtKB:Q5YKG4 (1) 385 aa
Sequence Information (all 13)
ORTHOLOGY for gna12a ( Chr: 3 )
CITATIONS (33)