ZFIN is now using GRCz12tu for Genomic Data
Gene
slc45a2
- ID
- ZDB-GENE-050208-97
- Name
- solute carrier family 45 member 2
- Symbol
- slc45a2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable sucrose:proton symporter activity. Acts upstream of or within melanocyte differentiation and response to light stimulus. Predicted to be located in membrane. Predicted to be active in melanosome membrane. Is expressed in several structures, including melanoblast; optic vesicle; pigment cell; presumptive retinal pigmented epithelium; and retina. Used to study cataract. Human ortholog(s) of this gene implicated in oculocutaneous albinism type IV and pigmentation disease. Orthologous to human SLC45A2 (solute carrier family 45 member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138762 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 33 figures from 16 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oculocutaneous albinism type IV | Alliance | Albinism, oculocutaneous, type IV | 606574 |
| [Skin/hair/eye pigmentation 5, black/nonblack hair] | 227240 | ||
| [Skin/hair/eye pigmentation 5, dark/fair skin] | 227240 | ||
| [Skin/hair/eye pigmentation 5, dark/light eyes] | 227240 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cataract | slc45a2b4/b4 | standard conditions | Takamiya et al., 2016 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Homologous_superfamily | IPR036259 | MFS transporter superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | MFS transporter superfamily |
|---|---|---|---|
| UniProtKB:A8WG95 | InterPro | 554 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc45a2-201
(1)
|
Ensembl | 1,745 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers