Gene

slc12a9

ID

ZDB-GENE-050208-222

Name

solute carrier family 12 member 9

Symbol

slc12a9 Nomenclature History

Previous Names

fk87c04
im:7146124
si:ch211-284e13.1
wu:fk87c04

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; chloride transmembrane transport; and potassium ion homeostasis. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in lysosomal membrane and plasma membrane. Orthologous to human SLC12A9 (solute carrier family 12 member 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7146124 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa9521	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa33660	Allele with one point mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this) European Zebrafish Resource Center (EZRC) (order this)
sa38493	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With slc12a9 Human Ortholog

No data available

Associated With slc12a9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004841	Amino acid permease/ SLC12A domain
Domain	IPR018491	SLC12A transporter, C-terminal
Family	IPR004842	SLC12A transporter family

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Domain Details Per Protein

Protein	Additional Resources	Length	Amino acid permease/ SLC12A domain	SLC12A transporter, C-terminal	SLC12A transporter family
UniProtKB:A2BFP5	InterPro	899
UniProtKB:A0A8M9PY34	InterPro	899

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 5

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	slc12a9-201 (1) Ensembl	Ensembl		2,987 nt	Select Tool ZFIN BLAST
mRNA	slc12a9-202 (1) Ensembl	Ensembl		4,466 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-225O7	CT025690	ZFIN Curated Data
Contained in	BAC	CH211-284E13	BX294181	ZFIN Curated Data
Encodes	EST	fk87c04	BE200561 BE201202
Encodes	EST	IMAGE:7146124	CK683781	Thisse et al., 2004

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001128548 (1)	2700 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX294181 (1)	171388 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A8M9PY34 (1)	899 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	SLC12A9	7	Ensembl:ENSG00000146828 Gene:56996 HGNC:17435 OMIM:616861	Conserved genome location (synteny) (1) Amino acid sequence comparison (2)
Mouse	Slc12a9	5	Ensembl:ENSMUSG00000037344 Gene:83704 MGI:1933532	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

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