Gene

polr3a

ID
ZDB-GENE-050208-103
Name
polymerase (RNA) III (DNA directed) polypeptide A
Symbol
polr3a Nomenclature History
Previous Names
  • fb81e09
  • im:7139382
  • wu:fb81e09
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Is predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription, DNA-templated. Predicted to localize to RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism and progeria. Orthologous to human POLR3A (RNA polymerase III subunit A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With polr3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism Alliance Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism 607694
Wiedemann-Rautenstrauch syndrome 264090
Associated With polr3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000722 RNA polymerase, alpha subunit
Domain IPR006592 RNA polymerase, N-terminal
Domain IPR007066 RNA polymerase Rpb1, domain 3
Domain IPR007080 RNA polymerase Rpb1, domain 1
Domain IPR007081 RNA polymerase Rpb1, domain 5
Domain IPR007083 RNA polymerase Rpb1, domain 4
Domain IPR035697 DNA-directed RNA polymerase III subunit RPC1, N-terminal
Domain IPR035698 DNA-directed RNA polymerase III subunit RPC1, C-terminal
Homologous_superfamily IPR038120 RNA polymerase Rpb1, funnel domain superfamily
Homologous_superfamily IPR042102 RNA polymerase Rpb1, domain 3 superfamily
Domain Details Per Protein
Protein Length DNA-directed RNA polymerase III subunit RPC1, C-terminal DNA-directed RNA polymerase III subunit RPC1, N-terminal RNA polymerase, alpha subunit RNA polymerase, N-terminal RNA polymerase Rpb1, domain 1 RNA polymerase Rpb1, domain 3 RNA polymerase Rpb1, domain 3 superfamily RNA polymerase Rpb1, domain 4 RNA polymerase Rpb1, domain 5 RNA polymerase Rpb1, funnel domain superfamily
UniProtKB:A0A0R4IV41 1390
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations