Gene
polr3a
- ID
- ZDB-GENE-050208-103
- Name
- polymerase (RNA) III (DNA directed) polypeptide A
- Symbol
- polr3a Nomenclature History
- Previous Names
-
- fb81e09
- im:7139382
- wu:fb81e09
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to contribute to RNA polymerase III activity. Predicted to be involved in transcription, DNA-templated. Predicted to localize to RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism and progeria. Orthologous to human POLR3A (RNA polymerase III subunit A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139382 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 7 | Alliance | Leukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadism | 607694 |
| Wiedemann-Rautenstrauch syndrome | Alliance | Wiedemann-Rautenstrauch syndrome | 264090 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000722 | RNA polymerase, alpha subunit |
| Domain | IPR006592 | RNA polymerase, N-terminal |
| Domain | IPR007066 | RNA polymerase Rpb1, domain 3 |
| Domain | IPR007080 | RNA polymerase Rpb1, domain 1 |
| Domain | IPR007081 | RNA polymerase Rpb1, domain 5 |
| Domain | IPR007083 | RNA polymerase Rpb1, domain 4 |
| Domain | IPR035697 | DNA-directed RNA polymerase III subunit RPC1, N-terminal |
| Domain | IPR035698 | DNA-directed RNA polymerase III subunit RPC1, C-terminal |
| Family | IPR045867 | DNA-directed RNA polymerase, subunit beta-prime |
| Homologous_superfamily | IPR038120 | RNA polymerase Rpb1, funnel domain superfamily |
| Homologous_superfamily | IPR042102 | RNA polymerase Rpb1, domain 3 superfamily |
| Homologous_superfamily | IPR044893 | RNA polymerase Rpb1, clamp domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA-directed RNA polymerase III subunit RPC1, C-terminal | DNA-directed RNA polymerase III subunit RPC1, N-terminal | DNA-directed RNA polymerase, subunit beta-prime | RNA polymerase, alpha subunit | RNA polymerase, N-terminal | RNA polymerase Rpb1, clamp domain superfamily | RNA polymerase Rpb1, domain 1 | RNA polymerase Rpb1, domain 3 | RNA polymerase Rpb1, domain 3 superfamily | RNA polymerase Rpb1, domain 4 | RNA polymerase Rpb1, domain 5 | RNA polymerase Rpb1, funnel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IV41
|
1390 | ||||||||||||
|
UniProtKB:A0A8M9PWI3
|
1402 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
polr3a-201
(1)
|
Ensembl | 5,493 nt |
Interactions and Pathways
No data available
Plasmids
No data available