Gene
unc119a2
- ID
- ZDB-GENE-050201-2
- Name
- unc-119 lipid binding chaperone a2
- Symbol
- unc119a2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable lipid binding activity. Acts upstream of or within Kupffer's vesicle development and visual perception. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in intercellular bridge and microtubule cytoskeleton. Is expressed in several structures, including adaxial cell; central nervous system; renal system; solid lens vesicle; and visual system. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wright et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014088Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 1 of 1
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cone-rod dystrophy 24 | Alliance | Cone-rod dystrophy 24 | 620342 |
| immunodeficiency 13 | Alliance | ?Immunodeficiency 13 | 615518 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GMP phosphodiesterase, delta subunit | GMP phosphodiesterase, delta subunit superfamily | Immunoglobulin E-set | PDE6D/unc-119 myristoyl-binding |
|---|---|---|---|---|---|---|
| UniProtKB:Q1RM42 | InterPro | 264 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
unc119b-201
(1)
|
Ensembl | 2,239 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-167L17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136476 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153871 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158496 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191603 | ZFIN Curated Data |
1 - 5 of 5
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040394 (1) | 2132 nt | ||
| Genomic | GenBank:BX005137 (1) | 156370 nt | ||
| Polypeptide | UniProtKB:Q1RM42 (1) | 264 aa |
- Cardenas-Rodriguez, M., Austin-Tse, C., Bergboer, J.G.M., Molinari, E., Sugano, Y., Bachmann-Gagescu, R., Sayer, J.A., Drummond, I.A. (2021) Genetic compensation for cilia defects in cep290/NPHP6 mutants by upregulation of cilia-associated small GTPases. Journal of Cell Science. 134(14):
- Harjula, S.E., Saralahti, A.K., Ojanen, M.J.T., Rantapero, T., Uusi-Mäkelä, M.I.E., Nykter, M., Lohi, O., Parikka, M., Rämet, M. (2019) Characterization of immune response against Mycobacterium marinum infection in the main hematopoietic organ of adult zebrafish (Danio rerio). Developmental and comparative immunology. 103:103523
- Jean, F., Pilgrim, D. (2019) Evolution and expression of the zebrafish unc119 paralogues indicates a conserved role in cilia. Gene expression patterns : GEP. 33:1-10
- Zang, L., Shimada, Y., Nakayama, H., Chen, W., Okamoto, A., Koide, H., Oku, N., Dewa, T., Shiota, M., Nishimura, N. (2019) Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus. Frontiers in genetics. 10:693
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Rainy, N., Etzion, T., Alon, S., Pomeranz, A., Nisgav, Y., Livnat, T., Bach, M., Gerstner, C.D., Baehr, W., Gothilf, Y., Stiebel-Kalish, H. (2016) Knockdown of unc119c results in visual impairment and early-onset retinal dystrophy in zebrafish. Biochemical and Biophysical Research Communications. 473(4):1211-7
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wright, K.J., Baye, L.M., Olivier-Mason, A., Mukhopadhyay, S., Sang, L., Kwong, M., Wang, W., Pretorius, P.R., Sheffield, V.C., Sengupta, P., Slusarski, D.C., and Jackson, P.K. (2011) An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes & Development. 25(22):2347-2360
- Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418
1 - 10 of 14
Show